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anti hypertensive
as
39
Pharmacology
Graduate
11/02/2010

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Term
hbj
Definition
hgv
Term
Chorothiazide
Definition

Anti hypertensive/ Diuretic

Thiazide diuretic

 

inhibits Na/Cl reabsorption in distal convoluted tubule

 

usefule in nephrogenic diabetes insipidus

 

SFX: sulfa drug, hypokalemia, hyperuricemia

Term
Hydrochlorothiazide
Definition

Anti hypertensive/ Diuretic

Thiazide diuretic

 

inhibits Na/Cl reabsorption in distal convoluted tubule

 

usefule in nephrogenic diabetes insipidus

 

SFX: sulfa drug, hypokalemia, hyperuricemia

Term
Chlorthalidone
Definition

Anti hypertensive/ Diuretic

Thiazide diuretic

 

inhibits Na/Cl reabsorption in distal convoluted tubule

 

usefule in nephrogenic diabetes insipidus

 

SFX: sulfa drug, hypokalemia, hyperuricemia

Term
Indapamide
Definition

Anti hypertensive/ Diuretic

Thiazide diuretic

 

inhibits Na/Cl reabsorption in distal convoluted tubule

 

usefule in nephrogenic diabetes insipidus

 

SFX: sulfa drug, hypokalemia, hyperuricemia

Term
Furosemide
Definition

Anti hypertensive/ Diuretic

Loop diuretic

 

inhibits Cl reabsorption in thick, ascending loop of Henle

 

SFX: hypokalemia, sulfa drug

Term
Bumetanide
Definition

Anti hypertensive/ Diuretic

Loop diuretic

 

inhibits Cl reabsorption in thick, ascending loop of Henle

 

SFX: hypokalemia, sulfa drug

Term
Ethacrynic Acid
Definition

Anti hypertensive/ Diuretic

Loop diuretic

 

inhibits Cl reabsorption in thick, ascending loop of Henle

 

SFX: hypokalemia, OTOTOXICITY

 

NOT A SULFA DRUG

Term
Torsemide
Definition

Anti hypertensive/ Diuretic

Loop diuretic

 

inhibits Cl reabsorption in thick, ascending loop of Henle

 

SFX: hypokalemia, sulfa drug

Term
Spironolactone
Definition

Anti hypertensive/ Diuretic

K sparing

 

DIRECT aldosterone antagonisst

 

SFX: hyperkalemia, GYNECOMASTIA

 

used in primary or secondaryt aldosteronism and liver cirrhosis

Term
Eplerenone
Definition

Anti hypertensive/ Diuretic

K sparing

 

DIRECT aldosterone antagonisst

 

SFX: hyperkalemia, GYNECOMASTIA

 

used in primary or secondaryt aldosteronism and liver cirrhosis

No CNS effects

Term
Amiloride
Definition

Anti hypertensive/ Diuretic

K sparing

 

INDIRECT Aldosterone inhibitor

inhibits liminal Na transport in collecting tubule

 

SFX: hyperkalemia

Term
Triamterene
Definition

Anti hypertensive/ Diuretic

K sparing

 

INDIRECT Aldosterone inhibitor

inhibits liminal Na transport in collecting tubule

 

SFX: hyperkalemia

Term
Clonidine
Definition

anti hypertensive

 

Central acting sympahtolytic

 

CNS alpha 2 agonist

 

SFX: water/na retention, sedation, sexual dysfunction

dry mouth, constipation

Term

Methyldopa

 

Definition

anti hypertensive

 

Central acting sympahtolytic

 

CNS alpha 2 agonist

 

SFX: water/na retention, sedation, sexual dysfunction

dry mouth, constipation

 

+ Coombs test hematologic immunodeficiency

Term
Guanethidine
Definition

Anti hypertensive

 

Adrernergic neuron blocker

 

Inhibits NE release

 

SFX: Water/Na retention, orthostatic hypotension, drowsiness, diarrhea, sexual disfunction

Term
Reserpine
Definition

Anti-hypertensive

Adrenergic Neuron Blocking Agents

 

 blocks uptake/storage of NorEp

 

SFX:depression, Parkinson's, nasal congestion, stiffness

 

Term

Atenolol

 

Definition

Anti hypertensive/ anti arrhythmic

 

Beta blocker

 

Mech: blocks beta receptor in heart, blocks beta renin release

 

SFX: fatigue, tremor, bronchoconstriction

 

Term
Esmolol
Definition

Anti hypertensive/ anti arrhythmic

 

Beta blocker

 

Mech: blocks beta receptor in heart, blocks beta renin release

 

SFX: fatigue, tremor, bronchoconstriction

 

short acting, IV used when rapid blockage needed

Term
metoprolol
Definition

Anti hypertensive/ anti arrhythmic

 

Beta blocker

 

Mech: blocks beta receptor in heart, blocks beta renin release

 

SFX: fatigue, tremor, bronchoconstriction

 

Term
propanolol
Definition

Anti hypertensive/ anti arrhythmic

 

Beta blocker

 

Mech: blocks beta receptor in heart, blocks beta renin release

 

SFX: fatigue, tremor, bronchoconstriction

 

Term
pindolol
Definition

Anti hypertensive/ anti arrhythmic

 

Beta blocker

 

Mech: blocks beta receptor in heart, blocks beta renin release

 

SFX: fatigue, tremor, bronchoconstriction

 

Term
Prazosin
Definition

Anti hypertensive

 

alpha adrenoceptor blocker

 

blocks postsynaptic alpha receptors

 

SFX: headache, sexual dysfunction

Term
Terazosin
Definition

Anti hypertensive

 

alpha adrenoceptor blocker

 

blocks postsynaptic alpha receptors

 

SFX: headache, sexual dysfunction

Term
Doxazosin
Definition

Anti hypertensive

 

alpha adrenoceptor blocker

 

blocks postsynaptic alpha receptors

 

SFX: headache, sexual dysfunction

Term
Labetalol
Definition

Anti hypertensive

 

mixed blocker

 

reduces vascular tone and heart rate

 

SFX: blocks both types of adrenergic receptors

Term
Carvedilol
Definition

Anti hypertensive

 

mixed blocker

 

reduces vascular tone and heart rate

 

SFX: blocks both types of adrenergic receptors

 

antioxidant

Term
Trimethaphan
Definition

anti hypertensive

 

ganglionic blocker

 

blocks ganglion

 

sympathoplegia/ parasympathoplegia

 

NO LONGER AVAILABLE

Term
Minoxidil
Definition

anti hypertensive

 

arterial vasodilator

 

opens up K channels, stabilizes resting potentials

 

SFX: hypertrichosis (hair growth)

 

potent long lasting

Term
Hydralazine
Definition

anti hypertensive

 

arterial vasodilator

 

releases NO

 

SFX: angina, arrhythmia, lupus

 

has 1st pass effect

Term
Diazoxide
Definition

anti hypertensive

 

arterial vasodilator

 

K channel openor

 

SFX: hyperglycemia

 

treats hypertensive emergencies

Term
Captopril
Definition

anti hypertensive

 

ACE inhibitor

 

decreases angiotensin II production

 

SFx: hyperkalemia, hypotension, dry cough

bad w/ Nsaids, birth defects 2nd and 3rd trimesters

No reflex sympathetic activation

1st choice in patients w/ chf

Term
Enalapril
Definition

anti hypertensive

 

ACE inhibitor

 

decreases angiotensin II production

 

SFx: hyperkalemia, hypotension, dry cough

bad w/ Nsaids, birth defects 2nd and 3rd trimesters

 

No reflex sympathetic activation

1st choice in patients w/ chf

Term
Lisinopril
Definition

anti hypertensive

 

ACE inhibitor

 

decreases angiotensin II production

 

SFx: hyperkalemia, hypotension, dry cough

bad w/ Nsaids, birth defects 2nd and 3rd trimesters

 

No reflex sympathetic activation

1st choice in patients w/ chf

Term
Ramipril
Definition

anti hypertensive

 

ACE inhibitor

 

decreases angiotensin II production

 

SFx: hyperkalemia, hypotension, dry cough

bad w/ Nsaids, birth defects 2nd and 3rd trimesters

 

No reflex sympathetic activation

1st choice in patients w/ chf

Term
Quinapril
Definition

anti hypertensive

 

ACE inhibitor

 

decreases angiotensin II production

 

SFx: hyperkalemia, hypotension, dry cough

bad w/ Nsaids, birth defects 2nd and 3rd trimesters

 

No reflex sympathetic activation

1st choice in patients w/ chf

Term
Losartan
Definition

anti hypertensive

 

Angiotensin II receptor blocker

 

SFX: less cough, agniodema

 

similar to ace inhibitors

Term
Valsartan
Definition

anti hypertensive

 

Angiotensin II receptor blocker

 

SFX: less cough, agniodema

 

similar to ace inhibitors

Term
Aliskirien
Definition

anti hypertensive

 

Direct Renin inhibitor

 

SFx: edema, diarrhea, gerd, elevated uric acid

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