Term
| What is the MOA of thiazides? |
|
Definition
| block Na reabsorption in distal tubule |
|
|
Term
What are the side effects of thiazide diuretics? (6)
3 of them effect
glucose
uric acid
K |
|
Definition
decrease serum K
incease uric acid
increase glucose
fatigue
parasthesias
impotence |
|
|
Term
What is the mechanism of action of ACE inhibitors?
What do they do to BP, CO, HR |
|
Definition
| they decrease angiotensin II so decrease BP w/o effect on CO/HR. They cause vasodilation of renal afferent thus naturesis. |
|
|
Term
| What are the adverse effects of ACE inhibitors? (3) |
|
Definition
cough
angioedema
hyperkalemia |
|
|
Term
| What individual is an ACE inhibitor contraindicated for? |
|
Definition
|
|
Term
| What do ACE inhibitors end in? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is the adverse effect of ARB? |
|
Definition
|
|
Term
| What are five indications for ARB? |
|
Definition
stroke
HTN
renal failure
diabetes
LVH
CHF |
|
|
Term
| Name seven indications for ACE I? |
|
Definition
MI
angina
renal failure
HTN
proteinuria
CHF
diabetes
stroke |
|
|
Term
| What can an ACE I be used for that an ARB cant? |
|
Definition
|
|
Term
What are the indications for B blocker?
What are they poor use for? |
|
Definition
angina
MI
CHF
poor use: renal failure, stroke, systolic blood pressure |
|
|
Term
| What are the indications of alpha blockers? |
|
Definition
|
|
Term
| What are the side effects of alpha blockers? |
|
Definition
orthostatic hypotension
tachy
heart failure |
|
|
Term
| What route makes central sympatholytics like clondine helpful? |
|
Definition
|
|
Term
| What is the problem with sympatholytics? |
|
Definition
| poorly tolerated due adverse effects |
|
|
Term
| What type of drugs are hydralazine and minoxodil? |
|
Definition
|
|
Term
| What are direct vasodilators useful in? |
|
Definition
refractory hypertension
pregnancy |
|
|
Term
| Which direct vasodilator is better for pregnancy? |
|
Definition
|
|
Term
| What is a specific side effect of hydralazine? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is hypertricosis and what drug causes it? |
|
Definition
| it is excessive hair and is caused by minoxodil |
|
|
Term
| Why do the direct vasodilators have a long effect but a short half life? |
|
Definition
| b/c they are bound to vascular tissue and slow/fasat acetylators |
|
|
