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Anti-HTN Vasodilators
Pharm 2 exam 2
26
Health Care
Graduate
03/03/2009

Additional Health Care Flashcards

 


 

Cards

Term
Vasodilators
Definition

CCB's

Hydralazine

Minoxidil

-Nitroprusside

Term
CCB's work by
Definition

preventing Ca ions from entering the pl.mem. of sm muscle->vasodilation -> decr PVR

 

Art>veins

Term
Which 2 CCB's reduce HR and CO as well as vasodilation?
Definition

Verapamil

Diltiazem

Term

CCB's DO NOT alter

Definition

glucose, lipids, uric acid, OR ELECTROLYTES

 

Term
CCB's are esp useful in what population?
Definition
AA
Term

SE CCB's

Definition

fatigue, HA, dizziness, flushing, peripheral edema

 

Verapamil-CONSTIPATION

Term

Caution when using CCB's in pts w/

Definition

SA node brady

AV node pt/complete block

decr contractility

Term
CCB's are used prophylactically to tx
Definition
Migraine HA's
Term

CCB's drug interactions

Definition
BB d/t similar effects and can alter HR
Term
Vasodilators do not inhibit
Definition

symp nervous system = NO PROBS W/

ORTHOSTATIC HYPOTN and IMPOTENCE

Term

Vasodilators are very good in treating HTN when combined w/

 

Definition

BB and diuretic

 

***Alone, physiological compensation cause inadequate tx!!

Term
MOA of Diazoxide and Minoxidil
Definition

activate K causing HYPERPOLARIZATION ->

art. relaxation

Term
MOA sodium nitroprusside
Definition

increase in cGMP-> sm mm. relaxation

d/t N.O. generation

Term

MOA Hydralazine

Definition
causes release of N.O. and activates K channels
Term
Metabolism of Hydralazine
Definition

N-acetylation

 

(some fast some slow, MONITOR)

Term
Hydralazine works by
Definition

INCR CO

 

d/t:  incr symp stimulation,

incr. renin

Na and H2O retention (use diuretic)

Term
Hydralzine uses
Definition

HTN ambulatory pts whose BP not controlled by duiretics + other drugs that disrups SNS signals

 

(diuretic + BB)

 

oral and IV

Term
Minoxidil is </> Hydralazine at reducing BP
Definition
>
Term
SE of Minoxidil
Definition

EXCESSIVE HAIR GROWTH

HA

nasal cong

tachy

palpitations

Term

Uses of Minoxidil

Definition

Sereve HTN (life-threatening)

HTN resistant to other forms tx

HTN w/ chronic renal dz

Term
Diazoxide is similar to what drugs
Definition
thiazides (w/o diuretic action)
Term
MOA Diazoxide
Definition

Activates K channels -> art relaxation -> incr. CO

 

also causes Na and H2O retention (diuretic)

Term
AE Diazoxide
Definition

Incr workload may ppt ischemia and Na and H2O retention

 

Hyperglycemia (No DM)

 

Stop labor when used in eclampsia

Term
Sodium Nitroprusside MOA
Definition

stimulates cGMP production -> relaxes VEINS and ARTS -> decr PVR and venous return

 

Does not inhibit symp reflexes -> incr HR

 

Incr renin

 

decr preload and afterload

Term
uses of sodium nitroprusside
Definition

HTN crisis

Tx severe HTN w/ acute MI and LV failure

Term
AE sodium Nitroprusside
Definition

toxicity of cyanide poisoning (delerium, psychosis)

N/V

HA

Hypothyroidism

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