Term
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Definition
| Selective Estrogen Receptor Modulators - want to block the receptor but they sometimes become estrogenic |
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Term
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Definition
A SERM for prevention/therapy of breast cancer
- Anti-estrogenic in breasts
- Estrogenic in the uterus
**Decreases BMD in pre-menopausal women. hot flashes! |
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Term
| How does Raloxifene work? |
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Definition
| - PO, also hot flashes but less side effects than tamoxifen |
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Term
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Definition
Selective estrogen receptor downregulator - purely anti-estrogen. Higher affinity for ER, for Tamoxifen resistance
- Fulvestrant - IM, hot flashes |
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Term
| How to LHRH agonists work? |
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Definition
Decrease lvl of LH/FSH --> less estrogen. SEe a spike for a week
- Goserelin - SQ, tumor flare |
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Term
| How do aromatase inhibitors work? |
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Definition
Aromatase necessary for conversion from testosterone to estradiol
- Exemestane - PO, decr BMD
- Anastrazole - PO, decr BMD
- Letrozole - PO, decr BMD
**Hot flashes |
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Term
| How do LHRH agonists work for prostate cancer? |
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Definition
Decrease in LH = decr in testosterone
- Leuprolide - IM/SQ, tumor flare, cardio disease
- Degarelix - SQ
- Abiraterone - blocks androgen biosynthesis by irreversibly inhibiting CYP17
**Decr BMD, incr risk of cardio disease, hot flashes |
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Term
| How does abiraterone work? |
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Definition
- Abiraterone - blocks androgen biosynthesis by irreversibly inhibiting CYP17
**Incr in cardio disease |
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Term
| What are androgen receptor blockers? |
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Definition
- Flutamide - PO
- Bicalutamide - PO
- Nilutamide - PO
- Enzalutamide - PO
** Hot flashes, cardio, BMD |
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