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Anti-Epileptics
Pharm II
20
Pharmacology
Graduate
09/08/2012

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Cards

Term
partial seizures
Definition
affect only part of the brain
Term
simple seizures
Definition
consciousness usually preserved
Term
complex seizures
Definition
consciousness usually impaired
Term
generalized seizures
Definition
involves both hemispheres, loss of consciousness
Term
Carbamazepine (Tegretol)
Definition
TX for epileptics- Na+ channel blocker; used for all partial and tonic-clonic seizures
Term
Oxcarbazepine (Trileptal)
Definition
TX for epileptics, less drug interactions
Term
Divalproex (Depakote, Depakote ER)
Definition
TX for epileptics- valproate + valproic acid; most effective for myoclonic seizures, CI in pregnancy
Term
Ethosuximide (Zarontin)
Definition
TX for epileptics- secondary agent in ansence seizures, block t-type calcium channels
Term
absence seizures
Definition
usually in childhood and often “grow out of them.” Brief unconsciousness (sec) with frequent staring/eye blinking movements
Term
myoclonic seizures
Definition
brief single or multiple muscle contractions.
Term
tonic-clonic (Grand mal) seizures
Definition
sudden unconsciousness with rigidity (tonic phase) followed by jerking of muscles (clonic phase) for varying periods.
Term
status epilepticus seizures
Definition
rapid, recurrent seizures
Term
febrile seizures
Definition
benign, but scary tonic/clonic convulsions in children.
Term
Gabapentin (Neurontin)
Definition
TX for epileptics- GABA anaglogue; partial and generalized seizures, neuropathic pain; elderly
Term
Lamotrigine (Lamictal)
Definition
TX for epileptics- inhibits glutamate and aspartate release, becoming more popular, elderly; AE Stevens-Johnson syndrome
Term
Phenytoin (Dilantin)
Definition
TX for epileptics- decrease repetitive firing by block Na+ and Ca+ channels; not for absence seizures;AE drug interactions, gingival hyperplasia, tetrogensis
Term
Fosphenytoin (Cerebyx)
Definition
TX for epileptics- pro-drug
Term
Pregabalin (Lyrica)
Definition
TX for epileptics- Ca++ channel blockade; neuropathic pain, fibromyalgia
Term
Tiagabine (Gabitril)
Definition
TX for epileptics- partial seizures, GABA reuptake inhibitor
Term
Topiramate (Topamax)
Definition
TX for epileptics- broad spectrum, partial and generalized seizures, migraine,
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