Shared Flashcard Set

Details

Anti-depressants
Terry's lecture on antidepressant medications
8
Medical
Graduate
11/20/2011

Additional Medical Flashcards

 


 

Cards

Term
List of SSRI's
Definition
  • fluoxetine
  • sertraline
  • paroxetine
  • fluvoxamine
  • citalopram
  • escitalopram
Term
SSRI's MOA & Side Effects
Definition
  • Inhibition of 5-HT reuptake
  • Inhibition of NE & DA reuptake
  • Blocaked of M1 muscarinic-cholinergic receptors
  • Bind at 5-HT2c (agonist) and sigma receptors
Side Effects:
- Nausea
- Sexual difficulties
- Fatigue
- Insomnia
- Dizziness
- Weight Gain
- Headache
Term
List of Serotonin and NE Reuptake Inhibitors (SNRIs)
Definition
  • Venlafaxine
  • Desvenlafaxine
  • Duloxetine
- Adverse effects similar to SSRI's
- Sustained increase in diastolic BP @ higher doses, requires BP monitoring
- May require titration to reduce nausea
Term
Mirtazepine
Definition

Noradrenergic & Specific Serotonergic Antidepressants (NaSSAs)

- antagonizes alpha-2, 5-HT2a, 5-HT2c & 5-HT3 receptors

 

Side Effects

- Sedation

- Weight Gain

Term
Bupropion
Definition

NE & DA reuptake Inhibitor (NDRI)

- Adverse Effects:

  • agitation, insomnia, weight loss
  • lowers seizure threshold
  • may worsen or precipitate psychotic symptoms
- Drug interactions
  • stimulants
  • DA agonists/antagonists
Term

Nefazadone

Trazadone

Definition

Serotonin Antagonist & Reuptake Inhibitors (SARI's)

  • Serotonin (5-HT2a) receptor antagonism & 5-HT reuptake inhibition
Adverse effects:
  • sedation & orthostatic hypotension
  • priapism (painful erections) from Trazadone
Term
TCAs
Definition

tryptyline or -pramine (doxepin is the only exception)

- Inhibition of 5-HT & NE reuptake

- Blockade of α1, H1 and M1 receptors

 

Side Effects

- Anticholinergic - dry mouth, blurred vision, urinary retension, constipation

- Antiadrenergic - orthostatic hypotension

- Cardio - tachycardia, conduction changes

- Sedation

Term

Phenelzine

Tranylcypromine

Definition

Monoamine Oxidase Inhibitors

 

Adverse Effects:

- Sedation or activation

- Orthostatic hypotension

 

Drug Interactions

- Tyramine

- SSRIs

- TCAs

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