Examples: Aricept, tacrine, Exelon, razadyne

MOA: centrally acting, reversible inhibition of ACh increases the amount availible to post-synaptic neuron

A/E: GI intolerance

Drug-drug: Synergistic with cholinergic

Antagonistic with anticholinergic

Fewest SE

only drug approved for all stages alzheimers

avail PO, ODT

CYP2D6, CYP3a4 inducers decrease levels of Aricept

A/E: HA dizziness

IR tab, skin patch (helps avoid GI sx), capsules

high incidence n/v

IR ER capsule, liquid

Glutamate/NMDA bind to receptor with  glycine to activate

important in controlling memory function

Class:NMDA receptor antagonist

MOA: helps reg glutamate which may be in excess in alzheimers pt

A/e: GI intolerance,HTN, Dizziness, HA

Metabolized: HEPATIC, RENAL 50/50

Can be used in combo with ACh inhibs