Term
|
Definition
| PNS end organs, sweat glands are SNS cholinergic, nucleus basalis of meynert |
|
|
Term
|
Definition
5 types
M2, M3 are most common
drugs are not specific |
|
|
Term
|
Definition
|
|
Term
|
Definition
Most BV, Urinary sphincter, pupil, pilomotor muscles
Muscle Contraction and vessel constriction |
|
|
Term
|
Definition
| Adrenergic nerve endings in CNS, salivary glands, BV of skin, mucosa, saliva, and splanchnic |
|
|
Term
|
Definition
| Heart, kidney, brain, adipose tissue |
|
|
Term
|
Definition
| Eye (inc Aq humor), glands, heart, BV (dilation), Airway (dilation), bladder, liver |
|
|
Term
|
Definition
| Ach, Carbachol, Methancholine, Bethanechol, Pilocarpine |
|
|
Term
| what structure do all M agonists have in common |
|
Definition
|
|
Term
| Reason for variability in M agonist structure |
|
Definition
| inhibit breakdown by cholinesterase |
|
|
Term
| M agonist contraindications |
|
Definition
| Asthma, bradycardia, HTN, CAD, peptic ulcer, Hyperthyroidism, weakened smooth muscle of bladder or GI (post sx for intestinal anastamoses), urinary or intestinal obstruction |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Tx glaucoma, but not used much |
|
|
Term
| what happens when Ach give a systemically |
|
Definition
| Rapid hydrolysis by Pseudocholinesterase |
|
|
Term
|
Definition
|
|
Term
| Carbachol- what does it stimulate |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Methacholine- what receptors does it stimulate |
|
Definition
|
|
Term
|
Definition
| pulmonary function tests for asthma |
|
|
Term
|
Definition
|
|
Term
| Bethanechol- Recetpros activity |
|
Definition
|
|
Term
|
Definition
| stim GI motility, stop urinary retention |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Cholinesterase inhibitors- Reversible |
|
Definition
Endrophonium
Physostigmine
Neostigmine
Pyridostigmine
Rivastigmine
Donepezil
Carbamae Insectecides |
|
|
Term
| Cholinesterase inhibitors- Irreversible |
|
Definition
Prathion- Oragophosphate insecticide
Sarin, and other nerve gasses |
|
|
Term
| Cholinesterase inhibitor OD symptoms |
|
Definition
SLUDGE
skeletal muscle- fasiculations --> paralysis
Bradycardia, hypotension, shock, severe miosis
CNS stim & seizure --> Coma
Chronic exposure --> demylenation |
|
|
Term
| Tx for cholinesterase inhibitor poisoning |
|
Definition
Atropine- 2-4 mg IV, every 10 min until symptoms alleviate
Paridoxime- w/in 2 hours, only works for organophosphates
Symptomatic tx |
|
|
Term
|
Definition
|
|
Term
|
Definition
Tensiolon test for MG
Very short acting |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Tx MG, prexposure antidotal tx for nerve gases in chemical warfare |
|
|
Term
|
Definition
|
|
Term
| Neostigmine- can it cross BBB |
|
Definition
|
|
Term
| Pyridostigmine- Can it cross BBB |
|
Definition
|
|
Term
| Physostigmine, Eserine-can it cross BBB |
|
Definition
|
|
Term
| Physostigmine, Eserine- Uses |
|
Definition
| Tx atropine or other anti M poisoning. used to be used for tricyclic poisoning or with antidepressants |
|
|
Term
|
Definition
|
|
Term
| Organophosphate insecticides- |
|
Definition
| Parathion, Malathion, Diazinon |
|
|
Term
| Organophosphate insecticide- MOA |
|
Definition
| Parathion, and Malathione are activated to paroxone and malaoxone. This occurs more rapidly in insects, and insects can't detoxify |
|
|
Term
| Can Parathion be absorbed through the skin? |
|
Definition
|
|
Term
| Signs and Symptoms of Organophosphate insecticide poisoning |
|
Definition
| signs of cholinesterase inhibitor poisoning |
|
|
Term
| Tx for oragonphosphate insecticide poisoning |
|
Definition
Atropine
Pralidoxime
Symptomatic support |
|
|
Term
| Carbamate Insecticides- Ex |
|
Definition
|
|
Term
| Can carbamate insecticides be absorbed through the skin? |
|
Definition
|
|
Term
| Carbamate insecticide poisoning- signs and symptoms |
|
Definition
| like other cholinesterase inhibitor |
|
|
Term
| Carbamate insecticides poisoning tx |
|
Definition
Atropine
Pralidoxime wont work |
|
|
Term
| DFP/ Isoflurophate- Nerve gas- MOA |
|
Definition
| irreversible cholinesterase inhibitor |
|
|
Term
| DFP/ Isoflurophate- Nerve gas- Name |
|
Definition
|
|
Term
| DFP/ Isoflurophate- Nerve gas- poisoning Signs and symptoms |
|
Definition
| like any other cholinesterase inhibitor |
|
|
Term
| DFP/ Isoflurophate- Nerve gas- poisoning Tx |
|
Definition
Atropine
Pralidoxime
symptomatic |
|
|
Term
| DFP and Isoflurophate- uses |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Pralidoxime/ 2PAM- function |
|
Definition
| Cholinesterase reactivator |
|
|
Term
|
Definition
| binds to Pi group that is inhibiting the cholinesterase and reactivates it |
|
|
Term
|
Definition
Organophosphate poisoning, use with in 2 hours
Doesn't work with carbamate insecticides |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Sildenafil, Vardenafil, Tadalafil |
|
|
Term
| Sildenafil, Vardenafil, Tadalafil- MOA |
|
Definition
|
|
Term
|
Definition
| visual disturbances, auditory disturbances, systemic vasodilation --> reflexive inc in HR |
|
|
Term
|
Definition
|
|
Term
| Vardenafil, Sildenafil- peak concentration |
|
Definition
|
|
Term
|
Definition
|
|
Term
| PDE5 inhibitors-metabolism |
|
Definition
|
|
Term
| PDE 5 inhibitor- drug interactions |
|
Definition
| ketoconazole, erythromycin, cimetidine, nitrates, Ca channel blockers, alpha1 blockers, sympathomimetics (cocaine, amphetamines) |
|
|
Term
| PDE-5 inhibitor- does adjustments |
|
Definition
|
|
Term
|
Definition
inhibits presynaptic Ach release.
ANS- anticholinergic effects
NMJ- paralysis |
|
|
Term
| Botlinum toxin- poisoning |
|
Definition
|
|
Term
|
Definition
| symptomatic support, esp pulmonary, Ig for toxin |
|
|
Term
| Botulinum toxin, medicinal uses |
|
Definition
BOTOX
opthamologic use as NMJ blocker
cosmetic |
|
|
Term
|
Definition
| Atropine, scopolamine, dicylomine, propantheline, glycopyrrolate, Ipratroprium, Tiatroprium, Benzotropine, Trihexyphenidyl, Troltrodine, Oxybutynin, Solifenacin, Tripicamide |
|
|
Term
| M anatagonists- Adverse events |
|
Definition
| Dry mouth, hot skin, constipation, urine retention, visual disturbances, blurred vision, photophobia, sedation, confusion, amnesia in elderly pations |
|
|
Term
|
Definition
glaucoma- esp narrow angle
Prostatic hypertrophy
CV instability
Sever Ulcerative colitis |
|
|
Term
| M antagonists- Acute poisoning- symptoms |
|
Definition
major problem b/c drugs are widely used
anticholinergic toxidrome
Dry hot skin
hyperthermia
severe mydriasis
blurred vision
photophobia
CNS stim- agitation, hallucinations, seizures --> Coma --> death
Cessation of GI mobility
weak, tachy pulse + arrythmia |
|
|
Term
| M antagonist poisoning- Tx |
|
Definition
Physostigmine- cholinesterase inhibitors
benzodiazepines for seizures
Ice baths to reduce hyperthermia
dark, quite area to reduce agitation and photophobia |
|
|
Term
| what else causes anticholinergic toxidrome |
|
Definition
anti histamines
anti psychotics
anti depressants |
|
|
Term
| Atropine & Homotropine- what plant |
|
Definition
|
|
Term
|
Definition
| Homotropine is conj to a methylbromide so cant enter CNS |
|
|
Term
|
Definition
| prototypical M antagonist |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Scopolomine vs Methscopolamine |
|
Definition
| Methscopoloamine is quaternary |
|
|
Term
| Scopolamine and methschopolamine- uses |
|
Definition
similar to atropine but more of a CNS depressent used to tx Sedation and Amnesia
Oral and Patch (transderm Scop)- prevent motion sickness and vertigo |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Intestinal antispasmodic to tx IBS |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
antesthesiology- preop med to dec respiratory secretions and inhibit vagal reflexes
widely used as general M antagonist |
|
|
Term
| Ipratropium & Tiatropium- Names |
|
Definition
|
|
Term
| Ipratropium & Tiaropium- class |
|
Definition
|
|
Term
| Ipratroprium & Tiaropium- Uses |
|
Definition
|
|
Term
| Ipratropium and Tiatropium- AE |
|
Definition
|
|
Term
| Ipratropium VS Tiatropium- |
|
Definition
| Tiatropium has longer duration |
|
|
Term
| Benztropine & Trihexyphenidyl- Name |
|
Definition
|
|
Term
| Benztropine & Trihexyphenidyl- Class |
|
Definition
| centrally acting M antagonists |
|
|
Term
| Benztropine & Trihyexyphenidyl- Uses |
|
Definition
Tx PD & drug induced PD
anti dopaminergics, Anti Psychotics, Antinemics |
|
|
Term
| Tolteradine, Oxybutyniin, Solifenacin- Names |
|
Definition
| Detrol, Ditropan, VESIcare |
|
|
Term
| Tolterodine, Oxybutynin, Solifenacin- class |
|
Definition
|
|
Term
| Tolterodine, Oxybutynin, and Solifenacin- Uses |
|
Definition
| Tx urinary incontinence from an over active bladder |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Midriacis during opthalomogic exam |
|
|
Term
| NMJ blockers- - competitive |
|
Definition
|
|
Term
| NMJ blockers- depolarizing agents- Name |
|
Definition
| Succinylcholine- Anectine |
|
|
Term
|
Definition
| cholinesterase inhibitor either competitive or depolarizing causes relaxation or paralysis of skeletal muscle |
|
|
Term
| NMJ blocking drugs- competitive- axn |
|
Definition
| produce Muscle relaxation |
|
|
Term
| NMJ blocker- competitve- tx |
|
Definition
| pyridostigmine, neostigmine- cholinesterase inhibitors |
|
|
Term
| NMJ blocker- depolarizing- axn |
|
Definition
| Initialy stims receptor to cause weak contractions (fasiculations) --> relaxation --> paralysis |
|
|
Term
| NMJ blockers- depolarizing- effect of cholinesterase inhibitors |
|
Definition
|
|
