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ANS Control Drugs
Parasympathetic/Sympathetic-Vasopressors
74
Pharmacology
Professional
06/12/2010

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Term
Cholinergic
Definition
Parasympathomemtic
Term
Cholinergic blockers
Definition
Parasympatholytic
Anticholinergic
Term
Adrenergic fibers
Definition
Sympathomimetic
Catecholamine
Term
Adrenergic blockers
Definition
Sympatholytic
Term
Cholinergic fibers
Definition
Nicotinic
Muscarinic
Term
Nicotinic effect of ACH
Definition
^hr/^bp/^skeletal muscle contraction
Term
Where do we have nicotinic receptors symp. and parasymp. nerve fibers
Definition
At the ganglia-which is why they seem sympathetic
Term
Muscarinic effects of ACH include
Definition
vhr/ vbp/ sludge m
Term
Muscarinic effects are blocked with what
Definition
Atropine Sulfate
Term
Atropine is a
Definition
Parasympatholytic
Term
Direct acting cholinergic drugs act
Definition
Directly on cholinergic receptors (muscarinic)
Term
Indirect acting cholinergic drugs act on
Definition
ACHE (acetycholinesterase) which degrades ACH
Term
Cholinergic blockers block what___________
at the _____________receptors
Definition
ACH
Muscarinic
Term
Atropine effects are what
Definition
Dose dependent
Term
How long do the effects of Atropine last
Definition
3-5 minutes
Term
Auto immune disorder
Destroys Nicotinic fibers
Skeletal muscle contraction weakness
Definition
Myesthenia Gravis
Term
Atropine is what classification
Definition
Parasympatholytic/ Anti-cholinergic
FOR NOW
Term
Atropine's MOA
Definition
block cholinergic receptors(muscarinic) which
^hr
block vagal tone
vGI secretion and motility
FOR NOW
Term
Indications for Atropine
Definition
Symptomatic bradycardia
Pre-medication for RSI
FOR NOW
organophosophate or nerve agent poisoning
Term
Catacholamines
Definition
Epi
Norepi
Dopamine
Seratonin(CNS)
Term
Catecholamines do what
Definition
^chrono/ino/dromo
^bp-vasoconstriction
^bronchodilation
regulation of body temperature
Term
Direct acting Cholinergic drugs act
Definition
directly on Alpha and Beta receptors
Term
3 naturally occurring catecholamines
Definition
epi
nor epi
dopamine
Term
Sympathomimetics have what effects
Definition
^ in all the following
inotropy
chronotropy
dromatrophy
BP/PVR
bronchodilation
Term
_________is a prototype
Definition
EPI
Term
What Catecholamine causes the less vasoconstriction and is dose dependent
Definition
dopamine
Term
Dopamine is given at .5-2mcg/kg/min effect what
Definition
renal vasodilation
Term
Dopamine effects Beta I receptors at what dose
Definition
2-10mcg/kg/min
Term
Dopamine given at doses >10mcg/kg/min works on what receptors
Definition
Alpha
Term
What Sympathomimetic/Vasopressor drug works mainly on force of contraction with very little chronotropic effects
Definition
Dobutamine
Term
What drugs are used before epi and nor epi to treat circulatory shock
Definition
Dopamine
Dobutamine
Term
What drugs cause positive inotropy and vasodilatory effects
Definition
Amrinone
Milrinone
Term
Amrinone and Milrinone would be used to treat what medical patient
Definition
CHF with HTN
Term
What drug can you use in place of epi and nor epi in a cardiac arrest
Definition
Vasopressin
Term
Vasopressors work because they are what
Definition
Sympathomimetics
Term
Sympathomimetics that only cause Beta I effects, are also called
Definition
Inotropes
Term
Contraindications for Vasopressors FOR NOW
Definition
HTN
Hypovolemia
Term
Epinephrine AKA
Definition
Adrenalin
Term
EPI classification
Definition
Sympathomimetic,Catecholamine
Inotropic agent
Vasopressor
Term
EPI MOA
Definition
Acts directly on alpha and beta receptors which
Increase the following
chrono, ino, dromo, pvr, bp, automaticity
Bronchial smooth muscle dilation
Term
EPI indications
Definition
Cardiac arrest
shock
hypertension
Term
Cardiac Arrest
Definition
asystole, PEA, V-fib, pulseless V-tach
Term
Vasopressin AKA
Definition
Pitressin
Term
Vasopressin classification
Definition
Vasopressor
Term
Vasopressin MOA
Definition
Smooth muscle contriction
Term
Indications for Vasopressin
Definition
Cardiac arrest
Term
Dopamine AKA
Definition
Intropin
Term
Dopamine classification
Definition
Sympathomimetic
Vasopressor
inotropic agent
Term
Dopamine MOA
Definition
Directly acts on alpha and beta receptors
Effects alpha more profoundly than beta
^renal, mesenteric, and coronary artery vaodilation in low doses
Term
Indications for Dopamine
Definition
Hypotension
Term
Dobutamine AKA
Definition
Dobutrex
Term
Dobutamine classification
Definition
Sympathomimetic
Vasopressor
Inotropic agent
Term
Dobutamine MOA
Definition
Directly on alpha and beta
Beta I specific
very little chrono effect
^ino/ ^dromo/ ^automaticity
Term
Indications for Dobutamine
Definition
CHF c mild hypotension 70-100mmg, tachy
Term
Norepinephrine AKA
Definition
Levophed
BIG GUN
Term
Nor epi classification
Definition
Sympathomimetic
Vasopressor
Term
Nor epi MOA
Definition
Directly acting on Alpha receptors, ^bp
Term
Indication for Nor epi
Definition
BP<70mmg sys
Term
Isopoterenol AKA
Definition
Isuprel
Term
Isoproterenal Classification
Definition
Sympathomimetic
Term
Isoproterenol MOA
Definition
Acts on beta I and beta II receptors
Term
Isoproterenol indications
Definition
Symptomatic bradycardia
Term
Metaraminol AKA
Definition
Aramine
Term
Metaraminol classification
Definition
Sympathomimetic
Vasopressor
Inotropic agent
Term
Metaraminol MOA
Definition
Similar to nor epi less potent
acts directly on A n B receptors of para and sympathetic NS
Term
Metaraminol indications
Definition
hypotension
cardiogenic shock
Term
Amrinone AKA
Definition
Inocor
Term
Amrinone classification
Definition
Inotropic agent
Term
Amrinone MOA
Definition
Fast acting inotrope
reduces preload and afterload by relaxing vascular smooth muscle
Term
Amrinone indications
Definition
Severe CHF c HTN refractory to other agents
Term
Milrinone AKA
Definition
Primacor
Term
Milrinone classification
Definition
Inotrope
Term
Milrinone MOA
Definition
Fast acting inotrope
mild vasodilator
Term
Indication for Milrinone
Definition
Severe CHF c HTN refractory to other agents
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