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ANS agonists
ANS agonists
20
Pharmacology
Professional
11/02/2011

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Cards

Term
Acetylcholine
Definition
Neurotransmitter
-look at muscarinic agonists and antagonists to see function
Botulinum toxin- AChE release inhibitor
Term
Epinephrine
Definition
-SC or IM in emergencies
-low conc: b1+b2= bronchodilate, vasodilate. INC HR and SBP!
-high conc: a effect
Term
Norepinephrine
Definition
-a+b1 effect= INC SBP and DBP
can raise BP in severe shock
Term
Dopamine
Definition
INC BP
used in ER for hypotension due to shock (but danger of tachycardia because at high doses effect b1)
Term
Amphetamine
Definition
Indirect Sympathomimetics
*crosses BBB
*INC NE--> INC BP
Term
Tyramine
Definition
Indirect Sympathomimetics- in some foods
-competitvely works again NE for for NET
-can inactivate MAO
SE: hypertensive crisis!
Term
Ephedrine
Definition
Sympathetic Modulators
-slower and less potent effect as EPI
common use:
bronchodilator
eye exam (mydriasis)
nasal degongestant (OTC)
Term
Reserpine
Definition
Sympathetic Modulators
Term
Guanethidine
Definition
Sympathetic Modulators
Term
*Phenylephrine
Definition
α1 selective agonist
*INC DBP
*relieves nasal congestion
Term
*Clonidine
Definition
α2 selective agonist
*hypertension
*Caution: abrupt withdrawal can cause Rebound HT!!
Term
*Alpha Methyldopa
Definition
α2 selective agonist
-prodrug
-antihypertensive agent
*SAFE for pregnancy!
Term
*Isoproterenol
Definition
Nonselective beta receptor agonist
b1 and b2 agonist!
INC SBP, DEC DBP
Term
Dobutamine
Definition
ß1 selective agonist (also α1)
-INC CO w/out reducing efficiency
-CHF
Term
Albuterol, Metaproterenol, Terbutaline
Definition
ß2 selective agonist
Term
Salmeterol, Formoterol
Definition
Long-acting ß2 selective agonist
Term
a1
Definition
smooth muscle contraction, vasoconsitriction
*α1 selective: Phenylephrine
*α2 selective:Clonidine, Alpha Methyldopa
Term
a2
Definition
-presynapic negative feedback
-posynaptic- inhibits insulin release from b-cells (islets)
Term
b1 (cardiac)
Definition
postive chronotropic, ionotropic, and dromotropic
Term
b2
Definition
-bronchi, liver, and vasculature of skeletal muscle= dilates and relaxes
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