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ANG 107: Quiz 3_Miller
UC Davis
19
Biology
Undergraduate 4
10/12/2019

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Term
Allele and geno freq
Definition
*how we think about geetic behavior of a pop
* help derive genetic comp of a pop
Term
Geno freq
Definition
f(RR)= N(RR)/N
f(Rr)= N(Rr)/N
f(rr)= N(rr)/N

N(xx): # ind w/ xx
N: total # ind
Term
Allele freq
Definition
f(R) = N(R)/2N
f(r) = N(r)/2N

N(x): (#ind XX)(2) + (#ind Xx)(1)
Term
Relationship between allele and geno freq
Definition
GIVEN GENO, FIND ALLELE
*if know geno, know allele b/c for a given geno freq, only 1 allele freq work

GIVEN ALLELE, FIND GENO
*if know allele freq, DONT know geno b/c lots of geno freq conform to 1set of allele
*have lots of geno freq that can conform to allele freq
*have multiple ways to get allele freq so dont know for sure
Term
probability
Definition
quantifying our belief in the possible outcomes of a future event
Term
independent
Definition
the outcome of 1 won't affect the outcome of another
Term
Types of Probability
Definition
JOINT P FOR INDEPENDENT EVENTS
*apply AND rule


MUTUALLY EXCLUSIVE
*1 outcome happens so the other cannot happen @ the same time
*apply OR rule
Term
Hardy Weinberg Equil
Definition
prediction of the relationship between allele and geno freq (when given allele, predicts geno freq)

*important b/c we can make predictions about breeding strats and see if they're successful
*useful when know geno b/c helps make predictions for how well a breeding plan will work
Term
HWE Equations
Definition
f(RR) = f(R)^2
f(Rr) = 2f(R)f(r)
f(rr) = f(r)^2

f(R)= p
f(r)= q

f(RR) = P
f(Rr) = H
f(rr) = Q

P=p^2
Q= q^2
H= 2pq

p+q=1
p^2 + 2pq + q^2 = 1
P + H + Q = 1
Term
Humans and HWE
Definition
*human pop conforms to HWE b/c we assume random mating to a specific locus
Term
selection
Definition
particular alleles are removed or enriched in a pop
Term
When to cull
Definition
CULLING NOT EFFECTIVE
*when ind is in a low freq in pop
*only eliminiating a small number of 'e' alleles and there are many in hetero state masked by dom E
*vast majority in hetero, and cant select against it in hetero state
*very difficult to remove a recessive allele w/ pheno selection
Term
Inbreeding Depression
Definition
*P of producing a delterious allele w/ a relative is high
*ind mate w/ relatives and prod offspring that are less fit b/c inc chances of pairing deleterious alleles (b/c relatives share alleles)
Term
Graphical HWE
Definition
*if you have recessive allele @ low freq, it only becomes present in hetero state, so cant select against w/ pheno selection
*@ low freq, most receessive deleterious alleles are in hetero state and cacnt be selected against
Term
Fitness
Definition
* w
* an organisms ability to contribute to the next gen
*takes into account survival and repro state

w= 1 <-- geno w/ highest freq
Term
selection coefficient
Definition
*how much a particular geno is selected against
*strength of selection agaisnt a geno allows to describe amore broad range of scenarios about a geno relative contrib to next gen
*influence how much allele freq changes in a single gen of selection
Term
fixation
Definition
bringing an allele to the freq =1 (meaning only allele present in a pop)
Term
Important Factors that influence how much an allele freq changes in a single gen of selection
Definition
1) SELECTION COEFF
* stronger seection --> more of a freq allele change

2) DOMINANCE PATTERN

3) STARTING ALLELE FREQ
Term
Graphing freq of advantageous alleles over time
Definition
COMPLETELY DOM A+ ALLELE
* arises in hetero state & rises in freq quickly but never goes to fixation b/c cant purge non-adv allele

COMPLETELY RECESSIVE A+ ALLELE
*if a recessive mutation arises its in hetero state & cant be selected for quickly but once it does, it eventually reaches fixation

NO DOMINANCE
*rises quickly and reaches fixation
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