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anesthetics
22
10
Pharmacology
Graduate
04/13/2012

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Term
Nitrous oxide
Definition
Only gaseous form of anesthetic used, others are volatile liquids
.47 blood/gas partition therefore very fast induction
LOW lipophilicity, therefore the partial pressure of NO rises quickly in the plasma
High arterial gas tension
MAC is 101 (101% of atmospheric pressure, obviously not possible so “incomplete”)
Can use with other GAs to reduce side effect of increased PaC02, decreased TPR (NO will actually increase TPR slightly)
Term
Methoxyflurane
Definition
13 blood/gas partition coefficient (very soluble in blood) therefore very slow induction..does not mean it is “hydrophilic” actually VERY lipophilic and binds to blood proteins as an INACTIVE reservoir
About 50% of absorbed dose is metabolized because of high solubility
Not used anymore
Term
Isoflurane
Definition
Intermediate induction, intermediate arterial gas tension
Decreased TPR as you increase dose
Drug of choice with high intracranial pressure patients
Less soluble so only 0.17% metabolized, relatively safe!
Term
Desflurane
Definition
.45 blood/gas partition therefore very fast induction, high arterial gas tension
Decreased TPR as you increase dose
Less soluble so only 0.02% metabolized, relatively safe!
Term
Sevoflurane
Definition
.65 blood/gas partition therefore very fast induction, high arterial gas tension
Decreased TPR as you increase dose, also decreases CO
Less soluble so only 3% metabolized, significant amounts can cause fluoride buildup so use for short outpatient procedures only
Term
Thiopental
Definition
Ultra-short acting barbiturate
Used for induction of anesthesia (helps pass excitatory phase quickly)
Rapid diffusion, rapid redistribution so not for long term use
Term
Propofol
Definition
Chemically unrelated to other IV anesthetics (oil at room temperature)
Emergence from anesthesia with propofol is more rapid than thiopental
Minimal postoperative confusion
Great drug for inducing anesthesia, smaller doses for sedation during intensive care
Term
Etomidate
Definition
Increase GABA transmission, by increasing the number of available GABA receptors, used for induction, codes. Very short acting, minimal depression of respiration and CV system, use in codes when you need to intubate
Term
Glycopyrrolate
Definition
Anticholinergic to minimize secretions from GA irritation of bronchial tubes
Term
dantrolene
Definition
Stabilize the sarcoplasmic reticulum without interfering with action potentials, used for malignant hyperthermia with anesthesia (genetic predisposition side effect of GAs)
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