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Anesthetics
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10
Pharmacology
Graduate
11/05/2011

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Term
Nitrous Oxide
Definition
Incomplete Anesthesia, No Muscle Relaxation, Used with other anesthetics to decrease Pa CO2, Rapid Onset/Recovery, Can Fill Body Cavities (sinuses), Huge MAC, Low Relative Lipophiliciy
Term
Methoxyflurane
Definition
Slow Induction, High Blood/Gas Partition Coefficient, Very Small MAC (very Potent), 50% Metabolized (Increased Fluoride leading to Nephrotoxicity)
Term
Isoflurane
Definition
Does not increase Cerebral Blood Flow or Intracranial Pressure, Intermediate Induction, Little Metabolism
Term
Desflurane
Definition
Rapid Induction/Recovery, Irritating to airway-Not good for extended time, Low Metabolism, Uses Special Vaporizer
Term
Sevoflurane
Definition
Rapid Onset/Recovery, Not Irritating to airway, Useful in Children, Even with low B/G Part Coef still 3% metabolized which can lead to the buildup of fluoride (nephrotoxic)
Term
Thiopental
Definition
Ultra-Short-Acting Barbiturate, Used for induction to skip phase 2, Rapid Redistribution-Short Action
Term
Propofol
Definition
Emulsion, Rapid Onset/Recovery, Minimal Post Anesthetic confusion, nausea and Vomiting, Smaller doses can be used as a sedative in the ICU Setting
Term
Etomidate
Definition
Increase GABA Receptor Availability, Rapid Induction, Short Action, Little to No effect on the Heart and Respiration, Inhibits 11-B-Hydroxylase
Term
Glycopyrrolate
Definition
Antimuscarinic- Amnesia, Prevent Bradycardia, prevent respiratory Tract secretions
Term
Dantrolene
Definition
Tx Malignant Hyperthermia by stabilizing SR Calcium Leak
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