Term
| glucoritocids vs. nsaids moa |
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Definition
NSaids block COX, inhibiting the formaiton ofg arachidonate to prostaglandin H2.
Glucoritoicds: block formaiton of phosplipids toarachidonate. |
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Term
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Definition
most are weak organic acids,
near complete oral absorpiton, with no differnece iwth fodo or not.
highly metaoblzied by cyp familites, the nglucornidated,
excreted renally.
98 percent protein boudn (suually albumin).
accumulati onat asites of lifnamamtion.
half lives vary. |
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Term
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Definition
| becomes saturted whe ntotal body load exceeds 600 mg. afterwards halflife rises dramatically. Alkalnization of urine will increase reate of exretion fo salicyalte and its conjugates |
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Term
| salicyaltes nad nsaids toxicity |
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Definition
| cox1 inhibition- administer with misprostol, PPI, or h! antagonist. Cox2 selelctivy shoud help. Also prolongs bleeding time. |
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Term
| salicylate unique toxicity |
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Definition
salicylism- headache , tinnitus, wcns depresison ,thirst etc.
severe salicaylte posioining- dose depepndant leadign ot metabolic acidosis , renal and respiarotry fialure. |
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Term
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Definition
| hepatoxicity, from depletion fo glutathione stores. dont use inalcohols or paitients with liver disease . |
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Term
| otehr aspisin/nsaids toxicity |
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Definition
prolongs gestation, interferance iwth renal function- worry about patients wit hdiminsihes renal blood flow- can retain sodium potasisu mand water. decreasign prostaglandisn will decrease gfr.
wil leffect closure of ductus aretiorus (requi res prostaglandin to remain patent. ). - so can reuslt in rpemature closure.
blcokign prostaglandin syntehiss resutls in shunting to lipoxygenace and increased produciton of luekotrientes (aspirin inteolerance syndrome).
stop nSAId use in advance of surgery . |
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Term
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Definition
| targets il-1. Recombinant protein - endogenosu protein- il-1 receptor antagonist. preventing receptor to il-1 by ianctivating the receptor. |
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Term
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Definition
| CTLA4 fused to fc portion of IGG, inhibiton fo activaiton of t cells. |
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Term
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Definition
| cytokine inhibitor :Qb to Il-6 receptor. |
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Term
| anti cyotkine therapy adverse effects |
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Definition
infection site reacitons ,infusion reactions.
cytopenias .
serious infections.
malignancies
hepatoxicity (ifnluxmiab) |
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Term
| contraindicaitons to anti cyotkine |
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Definition
active ifneciton, tb postiive, treawt latent tb first preexisting dmeyelinating disorders.
possibly teratogenic |
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Term
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Definition
| traditional such as metotrexate, leflunomide, etc. |
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Term
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Definition
| oldest non aspirin nsai, poorly toelrated |
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Term
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Definition
| topical gel naisad approve for OA |
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Term
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Definition
| proten prodrug converted to cox 2 inhbiitor |
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Term
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Definition
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Term
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Definition
| antidoe to acetampinoephen |
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Term
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Definition
| anticd20 monocloanl antibody, targets b cells |
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