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Amyloidosis
MS Module
25
Medical
Graduate
05/12/2009

Additional Medical Flashcards

 


 

Cards

Term
What is amyloid?
Definition
a fibrillar protein
Term
What dye will stain amyloid?
Definition
congo red
Term
What type of birefringence occurs with amyloid and its characteristic dye?
Definition
yellow-green birefringence
Term
What type of protein structure is amyloid?
Definition
Beta-sheet
Term
What occurs to the tissue and organs of a amyloidosis patient?
Definition
the tissue will atrophy, but the added amyloid will cause the organs themselves to enlarge
Term
What does the P component do for amyloid?
Definition
it is not actually amyloid but stabilizes it
Term
What part of amyloid does not stain with congo red?
Definition
P component
Term
WHere is the P component produced?
Definition
liver
Term
What are the two most common types of amyloidosis?
Definition
AA and AL
Term
Which amyloidosis is due to plasma cell production of light chains?
Definition
AL
Term
Which is the primary amyloidosis and which is the secondary?
Definition

primary is AL

secondary is AA

Term
Which amyloidosis acompanies inflammatory process?A
Definition
AA
Term
Which form of amyloidosis commonly presents with renal disease?
Definition
AA
Term
Which amyloidosis leads to an enlarged tongue?
Definition
AL
Term
What amyloidosis is the acute phase reactant SAA found in?
Definition
AA
Term
Which amyloidosis is associated with Mediterranian Fever?
Definition
AA
Term
What does the Mediterranian Fever cause?
Definition

intermitten acute attacks of pain

usually abdominal pain

Term
Which amyloidosis is commonly associated with Rheumatoid arthritis?
Definition
AA
Term
What organ do you not want to biopsy in diagnosis of amyloidosis? Why?
Definition
liver due to severe bleeding risk
Term
What form of amyloidosis is due to transthyretic (preamyloid)?
Definition
ATTR
Term

How many forms of the disease are there in ATTR?

 

What are they?

Definition

TWO

 

Cardiac

Familial

Term
What are the two types of cardiac ATTR and which is most common?
Definition

Senile (more common)

Familial

Term
Which form of cardiac ATTR is asymptomatic?  What is usually present on autopsy?
Definition

Senile

enlarged left atrium

Term
What does transthyretin do?
Definition
transports thyroxine
Term
How is amyloidosis diagnoised?
Definition
biopsy except in liver
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