Term
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Definition
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Term
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Definition
- antidote
- Cyanide poisoning adjunct
- Nitrate
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Term
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Definition
| Converts hemoglobin to methemoglobin, which reacts with cyanide and chemically binds with it, preventing any toxic effect. |
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Term
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Definition
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Term
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Definition
| none in the emergency setting |
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Term
| Adverse Reactions/Side Effects |
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Definition
- Headache
- Dizziness
- Weakness
- Increased ICP
- Shortness of Breath
- Orthostatic Hypotension
- Tachycardia
- Syncope
- Cyanosis of lips, fingernails, and palms (signs of methemoglobinemia)
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Term
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Definition
| Increased hypotensive effects with antihypertensives, alcohol ingestion, phenothiazines, or beta blockers. |
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Term
| Dosage and Administration |
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Definition
Adult:
1 to 2 ampules crushed and inhaled for 30 seconds of each minute until sodium nitrite is prepared or administered for 30 to 60 seconds every 5 minutes until patient is conscious.
Pediatric:
1 ampule crushed and inhaled for 30 seconds of each minute until sodium nitrite is prepared or administered for 30 to 60 seconds every 5 minutes until patient is conscious. |
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Term
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Definition
Onset: 30 seconds to 5 minutes
Peak: Varies
Duration: 5 to 10 minutes |
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