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Amiodarone
Class, Trade Name, Uses, etc...
6
Pharmacology
Not Applicable
08/09/2010
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Term
Antidysrhythmic
 Definition
Drug class of Amiodarone:
Term
Unlike other disrhythmics in that it acts directly on all cardiac tissues.

Prolongs duration of the action potential and refractory period without significantly affecting the membrane potential.

Relaxes smooth muscles, decreases vascular resistance, and increases coronary blood flow.

Blocks effects of sympathetic stimulation.
 Definition
Therapeutic Action of Amiodarone:
Term
Used to treat life-threatening ventricular and supraventricular dysrhythmias, particularly atrial fibrillation.
 Definition
Emergency use of Amiodarone:
Term
Adult dose: 150(alive)-300(dead)mg IV over 10 minutes.

Ped dose: 5mg/kg IV/IO rapid bolus. Maximum dose 15 mg/kg.
 Definition
Dosage for Amiodarone:
Term
Contraindicated in patients with a known sensitivity to the drug.

Cardiogenic shock, severe sinus bradycardia, or advanced AC block unless a pacemaker is available.

also use with caution during pregnancy (Category D)and in nursing women.
 Definition
Contraindications of Amiodarone:
Term
CNS: Muscle weakness, wasting numbness, tingling; fatigue, abnormal gait, dyskinesias, dizziness, paresthesia.

CV: Bradycardia, hypotension, Sinus arrest, Cardiogenic shock, CHF, dysrhythmias, AV block

Eye: Optic neuropathy, Blurred vision, permanent blindness, corneal degeneration, macular degeneration, photosensitivity

GI: Anorexia, nausea, vomiting, constipation,

Respiratory: Alveolitis, fever, dry cough, dyspnea, interstitial pulmonary fibrosis

Skin: Slate-blue pigmentation, photosensitivity, rash
 Definition
Side effects of Amiodarone:
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