Term
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Definition
- Recombinant Tissue Plasminogen Activator (rTPA)
- Activase
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Term
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Definition
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Term
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Definition
| The enzyme binds to the fibrinbound plasminogen at the clot site, converting plasminogen to plasmin. Plasmin digests fibrin strands of the clot, restoring perfusion. |
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Term
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Definition
- AMI
- Stemi
- Massive PE
- Acute Ischemic CVA
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Term
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Definition
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Term
| Adverse Reactions/Side Effects |
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Definition
- Intracranial Bleeding
- Headache
- Re-perfusion dysrhythmias
- Chest Pain
- Hypotension
- G.I. Bleed
- Nausea
- Vomiting
- Abdominal Pain
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Term
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Definition
| The risk of bleeding is increased by any medication that affects blood clotting (e.g. aspirin, heparin, warfarin), any medication that inhibits platelet aggregation (e.g. clopidogrel, dipyridamole , glycoprotein IIb/IIIa antagonist) |
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Term
| Dosage and Administration |
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Definition
Adult:
15 mg IV bolus over 2 minutes; then 0.75 mg/kg over 30 minutes (not to exceed 50 mg); then 0.50 mg/kg over 60 minutes; max total dose of 100 mg (other doses may be prescribed by medical direction). Acute ischemic stroke: 0.9 mg/kg IV (not to exceed 90 mg) infused over 60 minutes; administer 10% total dose in 1 minute and the rest over next 60 minutes.
Pediatric:
Safety not established |
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Term
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Definition
Onset: 30 Minutes
Peak: 60 Minutes
Duration: Variable |
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