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Alabama NUR 326 Test 2
University of Alabama Nursing, 326 Pharmacology
54
Medical
Undergraduate 3
09/10/2007

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Term
Cholinergic System
Definition
Uses acetylcholine; This is the chemical of memory, and it only regenerates when you sleep
Term
Dopaminergic System
Definition
Uses dopamine; Pleasure, violence, emotion...levels usually altered in mental illness
Term
GABA-ergic System
Definition
Uses GABA; Major inhibitory neurotransmitter
Term
Noradrenergic System
Definition
Uses norepinephrine; mostly an excitatory neurotransmitter
Term
Serotonergic System
Definition
Uses Serotonin; This makes you happy, increased levels with exercise, regulates sleep-wake cycle
Term
Amino-Acid System
Definition
Uses several amino acids: aspartate (excite), glycine(inhibit), glutamate(most important excitatory neurotransmitter in CNS)
Term
Synapse
Definition
Microscopic gap that seperates neurons
Term
Blood Brain Barrier
Definition
Protects the brain from bacteria. Has largest holes as neonate, which makes them more suseptable to harm.
Term
After release transmitters are removed by:
Definition
Reuptake, Diffusion, Enzymatic Destruction
Term
The hypothalamus connects what two systems?
Definition
Endocrine and Neurological
Term
Functions of hypothalamus
Definition
Produce oxytocin and ADH, regulate body temp, control blood pressure through vasomotor center, regulate anterior pituitary hormones, regulate food and water intake
Term
Medulla Oblongata
Definition
Forms vital cardiac, respiratory, and vasomotor centers
Term
Reticular Activating System
Definition
Receives impulses from all parts of the body, and decides which to transmit to the cerebral cortex
Term
Cerebellum
Definition
Coordinates muscular activity
Term
Basal Ganglia
Definition
Skeletal muscle tone and orderly activity
Term
Opiods
Definition
Relieve pain by inhibiting the release of substance P in the central and peripheral nerves.
Term
Major Opiod Receptors
Definition
Mu, Kappa, and Delta
Term
Acute Pain
Definition
Caused by injury, trauma, spasm, disease processes, etc. Described as sharp, lancing, or cutting pain.
Term
Chronic Pain
Definition
Pain lasting 3 months or longer
Term
Cancer Pain
Definition
Has characteristics of acute and chronic pain and it may be constant or intermittent.
Term
Somatic Pain
Definition
Described as sharp, burning, aching, gnawing, throbbing or cramping in skin, bone muscle, and soft tissue.
Term
Visceral Pain
Definition
Deep pain; organs
Term
Neuropathic Pain
Definition
Results from direct injury of peripheral pain receptors, nerves, or the CNS.
Term
Pain is Objective or subjective?
Definition
Subjective; It is what the patient says it is
Term
Opoid Agonist Prototype
Definition
Morphine
Term
Morphine Def.
Definition
A naturally occuring opium alkaloid used mainly to relieve severe acute or chronic pain
Term
What schedule drug is Morphine?
Definition
Schedule II
Term
How is morphine given?
Definition
PO, IM, Sub-Q, IV
Term
Contraindications of Morphine
Definition
liver disease,respiratory depression (< 12), lung disease, prostatic hypertrophy, ICP, and hypersensitivity
Term
Morphine antidote
Definition
naloxone (Narcan)
Term
Fentanyl (Sublimaze)
Definition
Only given transdermal route; 100x's more powerful that morphine
Term
Hydromorphone (Dilaudid)
Definition
10x's more powerful than morphine
Term
Opoid Agonist/Antagonists
Definition
Acts like an agonist or antagonist, depending on the receptor. Has a lower abuse potential, but also can cause withdrawal symptoms in addicts
Term
Examples of Opoid Agonist/Antagonists
Definition
Buprenorphine (Buprenex), Butorphanol (Stadol), Nalbuphine (Nubain)
Term
Opoid Antagonists
Definition
Reverses deep analgesia, CNS and resp depression, and other effects of agonists by preventing or displacing opoid binding (Narcan!!)
Term
Narcan Half-Life vs Morphine Half-Life
Definition
It is much shorter, so you must give repeated doses until the morphine wears off
Term
Main concern of cancer pain
Definition
Client comfort, NOT preventing durg addiction
Term
How often should cancer pain meds be given?
Definition
Around the clock
Term
Most common side effect of pain meds in Geriatrics:
Definition
Confusion
Term
What should you take to block prostaglandins?
Definition
Asprin
Term
COX1
Definition
formed in all tissues and cells, especially platelet, endothelial cells, GI tract and kidneys
Term
COX2
Definition
present in brain, bone, kidneys, DI tract, and female reproductive system
Term
Allopurinol
Definition
Used to prevent or treat hyperuricemia (gout)
Term
Colchicine
Definition
Anti-inflammatory druge used to prevent or treat acute attacks of gout
Term
Probenecid
Definition
Increases urinary secretion of uric acid
Term
Sulfinpyrazone
Definition
Not effective in active gout, but prevents or decreases tissue changes of chronic gout
Term
Imitrex
Definition
Used to treat migraine headaches; it is a Triptane
Term
Migranes are caused by:
Definition
Vasodialation
Term
Triptans
Definition
Selective serotonin 5-HT1 receptor agonists
Term
Ergotamine Tartrate
Definition
Constricts blood vessels; caffine increases the effects
Term
Dihydroergotamine Mesylate
Definition
Semi-synthetic ergotamine; less toxic and less effective than parent drug
Term
Neurotic
Definition
Gets on everyone else's nerves (Monk)
Term
Psychotic
Definition
Castle in the sky mentality (purple people)
Term
Benzodiazephine Prototype
Definition
Valium
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