Shared Flashcard Set

Details

Advanced Pharmacology
Chemotherapy
14
Medical
Graduate
12/12/2010

Additional Medical Flashcards

 


 

Cards

Term
What are the possible hemotologic toxcities?
Definition

*Myelosuppresion

-Most frequent

-Most common dose limiting toxcitiy

*Destruction of WBCs, Plt, and RBCs leading to:

-Leukopenia

-Thrombocytopenia

-Anemia

*Occurs around 10-14 days after first round of treatment

*Cell regrowth 24-48 days

Term
What are the four types of pulmonary toxicites associated with chemotherapy?
Definition

*Chronic Pneumonitis & Pulmonary Fibrosis

*Pulmonary HTN

*Acute Hypersensitivity Reaction

*Non-cardiogenic pulmonary edema

Term
What is the most common pulmonary toxicity that is irreversible with s/s of DOE, non-productive cough, fatigue, hypoxemia?
Definition
*Chronic Pneumonitis and Pulmonary Fibrosis
Term
Which drug is associated with lung toxicity?
Definition
*Bleomycin
Term
What are possible GI toxicities?
Definition

*Stomatitis

*Mucositis

*Intestinal desquamation

*Diarrhea or constipation

*N&V

Term
What cardiac toxicities can occur with chemotherapy?
Definition

*ECG changes and life threatening arrhythmias

*Pericarditis, pericardial effusion

*Myocardial Ischemia

*Cardiomyopathies

*CHF

*Commonly seen with Doxurubicin

Term
What drug is associated with cardiac toxicities?
Definition
*Doxurubicin
Term
What Renal toxicities are present with chemo?
Definition
*ATN, ARF, hemorrhagic cystitis
Term
What liver toxicities are present with chemo?
Definition

*Hepatic fibrosis

*Cirrhosis

Term
What drug is associated with renal toxicity?
Definition
*Cisplatin
Term
What neurotoxicities are associated with chemo?
Definition

*N&V

*Neuropathies and paresthesias 

-Common with Cisplatin and Vincristine

*Cranial nerve toxicities

*Muscle pain and weakness

*Sensory impairment such as otoxoicity and retinopathy

Term
What is important for combination chemotherapy?
Definition

*Use of different agents that act on different cycles of the DNA synthesis

*Drugs with different MOA

*Drugs with different dose-limiting toxicities

 

Term
What is the goal of combination chemotherapy?
Definition
*To administer the largest possible doses of each drug to achieve maximal cell kill
Term

What is the MOA of Tyrosine Kinase Inhibitors?

Ex: Imatinib (Gleevec), Traztuzumab (Herceptin)

Definition

Inhibitor specifically blocks the action of protein kinase

*Interferes with cell communication and growth thus preventing tumor growth

*Inhibits tyrosine kinase enzymes instead of non-specifically inhibiting dividing cells

Supporting users have an ad free experience!