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Advanced Pharmacology
Antidiabetics
14
Medical
Graduate
11/28/2010

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Cards

Term
What is type I DM?
Definition
*Always requires basal insulin, despite poor intake or NPO status, to prevent ketoacidosis
Term
What is type II DM?
Definition
*May or may not nor require insulin when they are NPO, depending on their residual insulin secretion and insulin resistance.
Term
What is the bodies normal insulin production?
Definition
*40-50 units per day
Term
What is the total daily exogenous dose of insulin for treatment of diabetes mellitus?
Definition
*Range of 20-60 units
Term
What is the goal of any regimen for a patient with DM?
Definition
*To minimize metabolic derangements and, most obviously, to avoid hypoglycemia
Term
What is the normal management of a patient who is IDDM in regard to the use of insulin the day of surgery?
Definition
*Half the usual NPH dose will suffice to maintain the patient throughout the day.
Term
How much will one unit of regular insulin lower the plasma glucose?
Definition
*25-50g/dL
Term
What drugs are sulfonureas and what do they do?
Definition

*Glyburide, glipizide, glimepiride

*Increases endogenous insulin secretion

*must have viable beta cells

*Don't take AM of surgery

Term
What are biguanides?
Definition

*Glucophage

*Decreases hepatic glucose production, decreases glucose absorption, Increases glucose uptake into skeletal muscle

Term
Is basal insulin such as Glargine (lantus) skipped the day of surgery?
Definition
*No given whether NPO or not.
Term
How should NPH be managed the day before and morning of surgery?
Definition

*Full dose of NPH the nigth before

*Half dose the morning of sugery

Term
What is the management of Glargine before surgery?
Definition
*Full dose is given regardless of AM or PM dosing or NPO status.
Term
What is a correction dose of insulin intended for?
Definition
*Intended to correct hypoglycemia that is not adequately treated with current regime
Term
What type of insulin is preferred for mealtime supplementation?
Definition
*Aspart (Novolog)
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