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Advanced Pharmacology
Herbs
52
Medical
Graduate
11/03/2010

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Cards

Term
Herbs from _______ and _________ seem to have a higher incidence of tampered components.
Definition
*Asia and China
Term
What are the four classes of herbs?
Definition

*1. Safe when used appropriately

2. Restrictions (Ok unless in one of the following classes)

-External use only

-Not used in pregnancy

-Not used while nursing

-Other restrictions as noted

3. Label must read "needs to be used only under the supervision of an expert qualified in the appropriate use of this substance"

4. Insufficient data

Term
What is an ingredient found in herbs that can cause liver carcinomas?
Definition
*Pyrrolizidine Alkaloids
Term
There are no regulation for Pyrrolizidine Alkaloids for how much can be contained in herbal supplements.  What problems other than Liver carcinogenisis can this cause?
Definition

*Jaundice

*Increased Liver Enzymes

*Hepatitis

*Severe Cholistasis

Term
What problems can Comfrey and Colts Foot cause?
Definition
*Carcinogenic and Hepatotoxic
Term
What problems are associated with Chaparral?
Definition
*Renal Toxic
Term
What problems are associated with Ephedra?
Definition

*Mania

*Arrythmias

*HTN

*Dependence

Term
What problems are associated with Licorice?
Definition
*Pseudoaldosteronism
Term
What problems are associated with Lobelia?
Definition

*Seizures

*Coma with overdose

Term
What problems are associated with Sassafras?
Definition
*Procarcinogen for liver
Term
According to ASA when should herbal medications be dcd?
Definition
*2 weeks prior to surgery
Term
When should Echinecea be dcd?
Definition
*ASAP
Term
When should Ephedra be dcd?
Definition
*at least 24 hours
Term
When should garlic be dcd?
Definition
*At least 7 days
Term
When should Ginko be dcd?
Definition
*36 hours prior to surgery 
Term
When should Ginseng be dcd?
Definition
*7 days prior to surgery
Term
When should St. John Wart be dcd?
Definition
*5 days prior to sugery
Term
What herb will have acute withdrawal symptoms if dcd suddenly?
Definition
*Kava
Term
What six herbs can inhibit platelet activating factor, decrease platelet aggregation, and Exaggerate effects of Anticoagulants?
Definition

*Ginko

*Garlic

*Ginger

*Ginsing

*Echinacea

*Chamomile

Term
What seven herbs can decrease blood sugar?
Definition

*Alfalfa

*Aloe

*Bitter Mellon

*Dandelion Root

*Eucalyptus

*Garlic

*Genseng

Term
What herb can increase blood sugar levels?
Definition
*Ephedra
Term
What 6 herbs can cause CNS stimulation?
Definition

*Feverfew

*St. John's Wart

*Goldenseal

*Mahaung

*Milk Thistle

*Yohimbine

Term
What four herbs can cause CNS Depression leading to potentiation of effects of barbiturates, benzodiazepines, and opioids?
Definition

*Chamomile

*Kava

*Lavender

*Passion Flower

Term
What herbs are commonly used for antidepressants?  What drugs should you use with caution if a patient is taking one of these herbs?
Definition

*St John's Wart, Passion Flower, Ma-haung, Yohimbine

*Caution with tricyclics, SSRI's, and MAOI's

Term
What CV effects does garlic have?
Definition
*Decreases BP
Term
What effect does Ephedra have on the CV system?
Definition

*Increases BP

*Palpitations

Term
What CV effects does Ginger have?
Definition

*Decreases HR

*Positive inotrope

Term
What CV effects does Gingsing have?
Definition

*Increase BP

*Increase HR

Term
What CV effects does Licorice have?
Definition
*Arrhythmias due to decreased K+
Term
What CV effects does black cohash have?
Definition
*Decrease HR peripheral vasodilation
Term
What are 9 of the most commonly used herbs?
Definition

*Echinacea

*Ephedra

*Garlic

*Gingko

*Ginseng

*Kava

*St. John's Wart

*Valerian

*Glucosamine Sulfate

Term
What is garlic primarily used for? What is its active ingredient?
Definition

*Antioxidant effects

*Also decreases hyperlipidemia, antimicrobial, antiplatelet, and fibrinolytic effects.

*Active ingredient- Allicin

Term
What is the largest concern with the use of garlic?  What are some other potential side effects?
Definition

*Bleeding- associated with bleeding diathesis

*Other: decreases BP, enhances peristalsis, may decrease blood glucose

*Caution with other drugs that have blood thinning properties.

*Excessive use may lead to decreased Hgb and lysis of RBC's.

Term
What negative effects can Ephedra have?
Definition

*CV: Cardiac arrhythmias, HTN, MI, Angina, and myocarditis

*Neuro: CVA's, Seizures (esp when comb. with caffeine)

*Psych: Mania, Psychosis or dependence

*Interactions with MAOIs

Term
What herb has 100x more reports to the US poison control centers as any other herb?
Definition
*Ephedra
Term

What herb is taken to increase resistance to stress and restore homeostasis- is also used for invigoration and fortification in times of stress, fatigue, and declining capacity to work and concentrate.

Also increases the T-Lymphocytes in addition to cytotoxic and natural killers.

Definition
*Ginseng
Term
What are the major concerns with use of Ginseng?
Definition

*Main concern is platelet inhibition

*Others: Decreased effect of analgesics, possible HTN, CNS stimulation, increased HR, potential for hypoglycemia.

Term
What herb is used as an antioxidant, for cerebral vascular/PVD, increases utilization and uptake of oxygen and glucose, also modulates neurotransmitters and stabilizes Ca membranes?
Definition
*Ginko Biloba
Term
What effects does Ginko biloba have?
Definition

*Vasodilation

*Inhibition of platelet aggregation (inhibits platelet activating factor)

*N/V- diarrhea

*Seizures

*Caution with other drugs that can anticoagulate

Term
What herb serves as a sleep aid, anxiolytic, potentiates GABA, has synergistic effects with sedatives, and has a case report of an alaprozolam coma?
Definition
*Kava
Term
What herb is sometimes called nature's prozac and 3% of all presurgical patients use this?  Also used for anxiety, cramps and chest congestion?
Definition
*St. John's Wart
Term
How does St. John's Wart exert its effects?
Definition
*Acts a nonspecific reuptake inhibitor of serotonin, dopamine and norepinephrine
Term
What are some effects St. John's wart can have?
Definition

*Topical treatment for burns

*Can decrease digoxin levels

*Can have CYP450 induction

*No MAOI and SSRI

*Potential interaction with vasoactive drugs

Term
What is the active ingredient in St. John's Wart?
Definition

*Hypercin

*Hyperforin

Term
What herb is used for a minor tranquilizer, anxiolytic and has active constituents that bind to GABA?
Definition
*Valerian
Term
What interactions with anesthesia can valerian have?
Definition

*May prolong anesthesia by potentiation of CNS effects of sedatives and opiates

*Can have dystonic reactions

*Pt can display acute withdrawal syndrome

Term
What herb is used as an aphrodisiac, stimulant, for erectile dysfunction and is an alpha 2 antagonist?
Definition
*Yohimbe
Term
What are the side effects of Yohimbe?
Definition

*Has a very high risk/benefit ratio

*Very cautious with TCA's, MAO, SSRI

*Don't use sympathomimetics

*Avoid tyramine containing foods

*Can cause HTN, Tachycardia

Term
What is used as an immune system stimulant, has antiviral activity, promotes release of TNF by lymphocytes?
Definition
*Echinacea
Term
What patients is echinacea contraindicated in?
Definition

*AIDS patients, MS and TB patients

*Transplant patients because use of echinacea can counteract immunosuppressive drugs.

Term

What herb is found naturally in our bodies in the form of amino sugar and is thought to play a role in cartilage formation and repair?

What is it used for?

Definition

*Glucosamine Sulfate

*For pain relief from osteoarthritis

Term
Where is glucosamine derived?  What patients should it be avoided in?
Definition

*Derived from lobster, crab, and shrimp shells

*Caution with diabetic patient as it can increase blood sugar and possibly those with shellfish allergy

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