Term
True or False:
Chronic Myeloproliferative Disorders (MPD) are pluripotential stem cell disorders. |
|
Definition
True
They are characterized by uncontrolled proliferation of cells |
|
|
Term
True or False:
With MPD's only one cell line if affected. |
|
Definition
False
All cell lines are affected, but one line is affected most in each category |
|
|
Term
True or False:
Maturation does not occur during a MPD |
|
Definition
|
|
Term
What disease is likely present given the following symptoms:
Increased platelets, increased fibroblasts, increased marrow fibrosis, extramedullary hematopoesis |
|
Definition
|
|
Term
| With polycythemia vera, what would one expect to appear in the lab results for an EPO test? |
|
Definition
| decreased to almost absent EPO |
|
|
Term
True or False:
Polycythemia vera decreases the blood viscosity. |
|
Definition
False
It increases viscosity |
|
|
Term
| With polycythemia vera, what would one expect to appear in the lab results for an LAP? |
|
Definition
| Increased LAP since it is not CML and there is an increase in WBC's |
|
|
Term
True or False:
A left shift is always present with polycythemia vera. |
|
Definition
|
|
Term
True or False:
Basophilia is one symptom associated with polycythemia vera. |
|
Definition
|
|
Term
With polycythemia vera, when you look at a bone marrow smear, would would you expect for the following:
Cellularity?
M:E ratio?
Any increase in particular cells? |
|
Definition
Hypercellular marrow
Normal M:E ratio
Increase in megakaryocytes (increase in platelets is typice of PCV so an increase in megakaryocytes is typical) |
|
|
Term
The following clinical symptoms are associated with which disease:
Pruritis, headache, weakness, weight loss, fatigue, hypertension, bleeding. (Proliferative disorder of the blood) |
|
Definition
|
|
Term
With treatment, what is the life expectancy/prognosis in an individual suffering from polycythemia vera?
W/O treatment? |
|
Definition
|
|
Term
| When observing a peripheral smear, you observe leukoerythroblastosis along with dacrocytes, abnormal platelets, and ovalocytes. You also take note that the RBC count is decreased. What disease is likely present? |
|
Definition
| Myelofibrosis with Myeloid Metaplasia |
|
|
Term
| In Myelofibrosis with Myeloid Metaplasia, what is significant about the bone marrow? |
|
Definition
| Hypocellular bone marrow with fibrotic features |
|
|
Term
| In a patient with Myelofibrosis with Myeloid Metaplasia the attending physician orders a LAP test. What results would you expect? |
|
Definition
| LAP should be normal to slightly increased |
|
|
Term
What disease are the following clinical features associated with:
Splenomegaly, pallor, petecchiae |
|
Definition
| Myelofibrosis with Myeloid Metaplasia |
|
|
Term
| Which proliferative blood disorder is defined by in markedly increased platelet count with extremely abnormal shape and size |
|
Definition
| Essential Thrombocythemia |
|
|
Term
| Bone marrow megakaryocytic hyperplasia is a laboratory finding associated with which proliferative blood disorder? |
|
Definition
| Essential Thrombocythemia |
|
|
Term
A 45 year old male enters the ER with thrombosis of the leg. The attending physician orders a CBC, LAP, and performs a bone marrow biopsy. The laboratory findings are as follows:
*Platelets markedly increased
*WBC 15,000 cells per uL
*RBC 5 million cells per uL
*LAP 85
*Increased megakaryocytes in bone marrow with abnormal morphology
What proliferative blood disorder is likely present? |
|
Definition
| Essential Thrombocythemia |
|
|
Term
A patient visits his family physician with complaints of vague malaise with an insidious onset. The physician orders a CBC and obtains the following results:
Blasts: 3%
Myelocytes: 10%
Metamyelocytes: 22%
Bands: 15%
PMN: 40%
Lymphocytes: 6%
Basophils: 2%
Monocytes: 2%
Based off of those results, the physician orders a LAP which shows a score of 6.
Which proliferative blood disorder is likely present |
|
Definition
| Chronic myelocytic leukemia |
|
|
Term
| The Philadelphia Chromosome translocation occurs between which two chromosomes? Which proliferative blood disorder is associated with the Philadelphia Chromosome? |
|
Definition
Translocation between 9 and 22
Chronic Myelocytic Leukemia |
|
|
Term
| What does the BCR/ABL rearrangement essentially describe? Which proliferative blood disorder is BCR/ABL associated with? |
|
Definition
BCR/ABL describes the Philadelphia Chromosome which is the translocation between 9 and 22
Chronic Myelocytic Leukemia |
|
|
Term
| Tyrosine Kinase is increased in which proliferative blood disorder? |
|
Definition
| Chronic Myelocytic Leukemia |
|
|
Term
| What is significant about the laboratory results in a patient suffering form Juvenile Chronic Myelocytic Leukemia? |
|
Definition
| The Philadelphia Chromosome is absent, therefore it is not a true CML |
|
|
Term
In a patient suffering from Juvenile Chronic Myelocytic Leukemia, what would one expect to see in the lab for the following tests:
WBC
RBC
Platelets
LAP
Muramidase |
|
Definition
WBC and Muramidase are the only levels that are increased
The rest of the lab values are decreased |
|
|
Term
| An extreme anemia with a decrease in platelets should alert you for what? |
|
Definition
|
|
Term
| What type of testing refers to cell maker identification by flow cytometry? |
|
Definition
|
|
Term
| Which form of leukemia is often positive for tartrate-resistant acid phosphatase (TRAP)? |
|
Definition
|
|
Term
| The special stain, esterase, is often used for...? |
|
Definition
| Differentiating between myelocytic and monocytic cell lines |
|
|
Term
True or False:
Specific esterase is negative in granulocytic cells |
|
Definition
|
|
Term
| Non-specific esterase is present in which cell lines? |
|
Definition
| Monocytic, megakaryocytes, and some granulocytes |
|
|
Term
| A focally positive non-specific esterase is significant in the diagnosis for which leukemia? |
|
Definition
|
|
Term
| What type of cells contain myeloperoxidase? |
|
Definition
|
|
Term
| What does myeloperoxidase differentiate between? |
|
Definition
| Acute non-lymphocytic leukemia and acute lymphocytic leukemias (ANNL vs ALL) |
|
|
Term
True or False:
Myeloperoxidase has NO presence in monocytic cells |
|
Definition
False
A small amount of myeloperoxidase is present in monocytic cells |
|
|
Term
| The purpose of a PAS stain is to stain ___________ in cells? |
|
Definition
|
|
Term
| Neoplastic lymphoid cells and erythroleukemia show block positivity when which special stain is applied? |
|
Definition
|
|
Term
| Sudan black B is a special stain which stains ___________ in cells? |
|
Definition
|
|
Term
This special stain is positive in all of the following:
granulocytes, monocytes, megakaryocytes, and red cells of erythroleukemia |
|
Definition
|
|
Term
| Which special stain would you use to differentiate between basophilic leukemia and mast cell disease? |
|
Definition
|
|
Term
| Specifically which cells and where at within those cells would you find a positive TdT reaction? |
|
Definition
| Within the nucleus of lymphoblasts |
|
|
Term
| Which special stain would you use to distinguish lymphoblastic disorders? |
|
Definition
|
|
Term
| If TdT is positive, what indication will that have on a myeloperoxidase test? |
|
Definition
| Myeloperoxidase will be negative |
|
|
Term
| How is muramidase excreted from the body? |
|
Definition
|
|
Term
| Which leukemia would you want to observe the CSF? What are you looking for when observing the CSF? If what you are looking for is found, what type of therapy would be required and why? |
|
Definition
ALL
Looking for blasts. If they are found then intrathecal chemotherapy is required because typical chemotherapy cannot cross the blood-brain barrier |
|
|
Term
| What is the formal name for the leukemia M0? |
|
Definition
| Acute undifferentiated leukemia |
|
|
Term
| What type of cell dominates in acute undifferentiated leukemia? |
|
Definition
|
|
Term
| What would be the results of cytochemical staining in a patient suffering from acute undifferentiated leukemia? |
|
Definition
| cytochemical stains would be negative |
|
|
Term
| Acute myelocytic leukemia with minimal maturation is given which M* name? |
|
Definition
|
|
Term
What are the following results in a patient suffering from acute myelocytic leukemia with minimal maturation:
Myeloperoxidase
Sudan Black B
TdT
Specific esterase
Non-specific esterase |
|
Definition
Myeloperodiase (+)
Sudan Black B (-)
TdT (-)
Specific esterase (+)
Non-specific esterase (-) "or weakly positive" |
|
|
Term
| Leukemic hiatus is a condition associated with which myelocytic leukemia? |
|
Definition
| Acute myelocytic leukemia with minimal maturation |
|
|
Term
| What is a likely percentage of blasts in a patient suffering from acute myelocytic leukemia with minimal maturation? |
|
Definition
|
|
Term
| What condition differentiates AML from CML? |
|
Definition
|
|
Term
| What is the formal name for M2 leukemia? |
|
Definition
| Acute myelocytic leukemia with maturation |
|
|
Term
| Which form of leukemia is associated with t(15;17) (q22;q12) |
|
Definition
| Acute promeylocytic leukemia |
|
|
Term
| Why was acute promyelocytic leukemia very dangerous at one point? |
|
Definition
| Because of the promyleocytes present, they contain primary granules which stimulated teh coagulation cascade often times causing DIC leading to the patients bleeding out naturally or from chemotherapy |
|
|
Term
| Fagot cells are associated with which form of leukemia? |
|
Definition
| Acute promyelocytic leukemia |
|
|
Term
| Trans-retinoic acid is the treatment of choice for which form of leukemia? |
|
Definition
| Acute promyelocytic leukemia |
|
|
Term
Acute myelomonocytic leukemia shows what for the following lab tests:
Myeloperoxidase
Sudan black B
Specific esterase
Non-specific esterase
Muramidase |
|
Definition
|
|
Term
| Soft tissue tumors are often associated with which form of leukemia? |
|
Definition
| Acute myelomonocytic leukemia |
|
|
Term
| What is the predominant cell associate with acute myelomonocytic leukemia? |
|
Definition
| WBCs with convoluted nuclei |
|
|
Term
| Naegli leukemia is another name for which form of leukemia? |
|
Definition
| Acute myelomonocytic leukemia |
|
|
Term
| Schillings leukemia is another name for...? |
|
Definition
|
|
Term
| What is the predominant cell in acute monocytic leukemia? |
|
Definition
|
|
Term
| What is the predominant cell in the bone marrow in a patient with acute monocytic leukemia? |
|
Definition
|
|
Term
What is the results for the following lab tests in a patient suffering from acute monocytic leukemia:
Myeloperoxidase
Sudan Black B
non-specific esterase
Muramidase |
|
Definition
Myeloperoxidase: negative to weakly positive
Sudan black b: negative to weakly positive
N/S esterase: +
Muramidase: + |
|
|
Term
| Which form of leukemia is classified by organ involvement? |
|
Definition
|
|
Term
| Another name for erythroleukemia is...? |
|
Definition
|
|
Term
The following findings are associated with which leukemia:
N/N anemia, nRBC's, small amount of blasts, thrombocytopenia, PAS block positivity, megaloblastoid bone marrow |
|
Definition
|
|
Term
| Acute megakaryocytic leukemia will often show what in the peripheral blood? |
|
Definition
| Immature megakaryocytes, normal platelet count, giant platelets |
|
|
Term
True or False:
Acute megakaryocytic leukemia is positive for alpha-naphthyl butyrate and naphthol AS-D chloroacetate
(both of these are N/S esterases) |
|
Definition
False:
Although they are both N/S esterases, acute megakaryocytic leukemia is negative for alpha-naphthyl-butyrate but it is positive for naphthol AS-D chloroacetate. |
|
|
Term
On terms of being benign or malignant, rank the following from most benign to most malignant:
Myeloproliferative disorders
Acute leukemias
Myelodysplastic syndromes
Reactive leukocytosis |
|
Definition
Reactive leukocytosis
Myeloproliferative disorders
Myelodysplastic syndromes
Acute Leukemias |
|
|
Term
| All of the refractory anemias fall under which category on the spectrum of granulocytic proliferation disorders? |
|
Definition
| Myelodysplastic syndromes |
|
|
Term
| Chronic myelomonocytic leukemia falls under which category on the spectrum of granulocytic proliferation disorders? |
|
Definition
| Myelodysplastic syndromes |
|
|
Term
| Chronic myelocytic leukemia falls under which category on the spectrum of granulocytic proliferation disorders? |
|
Definition
| Myeloproliferative disorders |
|
|
Term
| GM-CSF stimulates production of what two types of cells? |
|
Definition
| Granulocytes and macrophages |
|
|
Term
| G-CSF stimulates production and enhances the function of which type of cells? |
|
Definition
|
|
Term
| M-CSF stimulates the production of which cell line? |
|
Definition
| macrophage-monocyte cell line |
|
|
Term
| What works with CSFs to stimulate WBC production and maturation? |
|
Definition
|
|
Term
| Through what structures do WBC's enter the peripheral blood? |
|
Definition
|
|
Term
| What process describes blood cells crossing from marginating pool to circulating pool? |
|
Definition
|
|
Term
| What is the function of chemotactic factors? |
|
Definition
| Attract granulocytes to infection or injury site where phagocytosis of foreign objects occurs |
|
|
Term
True or False:
Myeloperoxidase production occurs early in the myeloblast stage. |
|
Definition
False
occurs in the late myeloblast stage |
|
|
Term
True or False:
The metamyelocytes are the last stage which can undergo reproduction (mitosis) |
|
Definition
|
|
Term
| What 2 types of cells are found in the storage pool? |
|
Definition
|
|
Term
| What is the principle behind the marginating pool? |
|
Definition
| 50% of cells in peripheral blood adhere to the endothelium and may be released quickly during stress, exercise, labor, or infection |
|
|
Term
| What structure on neutrophils enhances phagocytosis? |
|
Definition
| Opsonins (process is opsonization) |
|
|
Term
| A bacterial infection will show in increase in which cell type? |
|
Definition
|
|
Term
| Which 3 types of anemia are associated with neutropenia? |
|
Definition
|
|
Term
| ACTH administration will decrease which cell line? |
|
Definition
|
|
Term
True or False:
A pyknotic nucleus is likely the result of a viral infection |
|
Definition
|
|
Term
| Hypersegmentation of the neutrophils occurs from which two types of anemia's? |
|
Definition
|
|
Term
| Heterozygous Pelgeroid cells look like? |
|
Definition
|
|
Term
| Homozygous pelgeroid cells look like? |
|
Definition
|
|
Term
| An inactivated X chromosome under the nuclear appendages category is referred to as...? |
|
Definition
|
|
Term
|
Definition
| Pale blue staining areas in the cytoplasm of pmns. They are composed of residual RNA from hurried development |
|
|
Term
|
Definition
|
|
Term
True or False:
Prolonged contact with heparin may result in the formation of Dohle Bodies? |
|
Definition
|
|
Term
| Primary granules containing lysozymes are known as? |
|
Definition
|
|
Term
| When would one see toxic vaculoization? |
|
Definition
| as bacteria are phagocytized and digested by the neutrophils |
|
|
Term
| Lupus Erytheroid cells are... |
|
Definition
| homogenous nuclear masses occupying most of the cytoplasm of the cell that has engulfed it. |
|
|
Term
| Alder Reilly anomaly is often confused with... |
|
Definition
|
|
Term
| In this anomaly, an abnormal deposition of mucopolysaccharides are within a cells cytoplasm which prevents the mucopolysaccharides from being broken down. |
|
Definition
|
|
Term
True or False:
Alder Reilly anomaly is autosomal dominant |
|
Definition
|
|
Term
| Large acidophilic granules in the WBC cytoplasm is an indicator of which disorder? |
|
Definition
|
|
Term
| Why are patients with Chediak Higashi albino? |
|
Definition
| Because the granules interfere with melanocytes |
|
|
Term
True or False:
Thromocytemia is often a concern with Chediak Higashi syndrome |
|
Definition
False
platelet count and function decrease leading to hemorrhage, not clotting |
|
|
Term
| This WBC anomaly is autosomal dominant and presents giant platelets and thrombocytopenia. The cytoplasm appears to have Dohle body like inclusions. |
|
Definition
|
|
Term
| Clover shaped WBC nucleus is referred to as...? |
|
Definition
|
|
Term
| If you suspect platelet satellitism, what type of tube should you request blood be collected in? |
|
Definition
|
|
Term
| If there is a precipitation of Wright's stain, what should you do? |
|
Definition
| Make sure the filter buffer pH is 7.0 to assure proper staining |
|
|
Term
True or False:
Smudge cells are cells that have their cytoplasm stripped away. |
|
Definition
|
|
Term
| This cell looks like a monoblast, however, the nucleus is foamy and the cytoplasm is blue/gray |
|
Definition
|
|
Term
True or False:
One cause of monocytosis is chronic parasitic infestations |
|
Definition
|
|
Term
| Autoimmune hemolytic anemia is characterized by what process? |
|
Definition
|
|
Term
| Peripheral blood pancytopenia is another name for this disease. |
|
Definition
|
|
Term
| This disease is characterized by the monocytes not being able to degrade glucocerebrosides. There are also large macrophages with wrinkled cytoplasm present. |
|
Definition
|
|
Term
| This disease is characterized by the inability to degrade sphingomyelin and cholesterol. |
|
Definition
|
|
Term
| What is the appearance of a Niemann-Pick cell in the bone marrow? |
|
Definition
| A large macrophage with foamy cytoplasm |
|
|
Term
| What is the appearance of a Niemann-Pick cell in the peripheral blood? |
|
Definition
| monocytes and lymphocytes with vacuolization |
|
|
Term
True or False:
Sea-Blue histocytosis occurs in the peripheral blood. |
|
Definition
False
This occurs only in the bone marrow |
|
|
Term
| Large macrocytes with blue-green cytoplasm within the bone marrow is defining of which disease? |
|
Definition
|
|
Term
| Vacuolation of peripheral lymphocytes and bone marrow histocytes is defining of which disease? |
|
Definition
|
|
Term
| What cell is expected to be abnormal in a person suffering from Brodetella pertussis? |
|
Definition
| Lymphocytes (variant lymphs are pesent) |
|
|
Term
True or False:
Variant lymphocytes are present during a hepatitis infection |
|
Definition
|
|
Term
True or False:
T and B cells migrate to the peripheral blood and then to the lymph nodes |
|
Definition
False
lymph nodes -> peripheral blood |
|
|
Term
True or False:
80% of peripheral lymphocytes are B lymphocytes |
|
Definition
|
|
Term
| What type of cells is a non-b/non-t lymphocyte? |
|
Definition
|
|
Term
| What is the function of a CD4 cell? |
|
Definition
| Assist macrophage in the activation of B lymphocytes |
|
|
Term
| What type of lymphcyte eliminates cells that carry specific antigens? |
|
Definition
|
|
Term
| What is the function of Delayed hypersensitivity T lymphocytes? |
|
Definition
| Produce lymphokines that attract macrophages to the site of infection and confine them to the infected area |
|
|
Term
True or False:
T lymphocytes transform into plasma cells with the purpose of producing antibodies |
|
Definition
False
B lymphcytes transform with the aid of T lymphocytes and macrophages into plasma cells |
|
|
Term
| When would heterophile antibodies show up (if at all) during reactive lymphocytosis not associated with mononucleosis? |
|
Definition
|
|
Term
| When would heterophile antibodies show up (if at all) during reactive lymphocytosis associated with mononucleosis? |
|
Definition
|
|
Term
True or False:
The Epstein Barr virus titer is negative during a CMV infection |
|
Definition
|
|
Term
| A single large granule in the cytoplasm of lymphcytes and multiple granules in neutrophilic cytoplasms is defining of which disease/anomaly? |
|
Definition
|
|
Term
| Which leukemia do smudge cells appear in? |
|
Definition
|
|
Term
|
Definition
| plasma cell in bone marrow with berry-like appearance |
|
|
Term
| What 2 disorders are associated with Mott cells? |
|
Definition
| hypergammaglobulinemia and multiple myeloma |
|
|
Term
|
Definition
inclusions in plasma cells of the bone marrow
(included in Mott cells) |
|
|
Term
With ALL what are the following results of these special stains:
Myeloperoxidase
Sudan Black B
PAS
TdT |
|
Definition
Myeloperoxidase -
Sudan black B -
PAS +
TdT + |
|
|
Term
| What cell predominates in ALL of adulthood? |
|
Definition
| Heterogenous large blasts |
|
|
Term
| What cell predominates in ALL of childhood? |
|
Definition
|
|
Term
| What is the appearance of blasts in Burkitt's leukemia? |
|
Definition
| Homogenous blasts with vacuoles and deep blue cytoplasm |
|
|
Term
True or False:
TdT is positive in Burkitt's Leukemia |
|
Definition
|
|
Term
True or False:
PAS is positive in Burkitt's Leukemia |
|
Definition
|
|
Term
True or False:
In T-Cell ALL the malignant cell is identical to T-lymphoblastic lymphoma |
|
Definition
|
|
Term
| Mediastinal masses and hepatosplenomegaly are common in which form of ALL? |
|
Definition
|
|
Term
True or False:
TdT is negative during T-cell ALL |
|
Definition
|
|
Term
| Which form of ALL predominates in both adult and childhood cases? |
|
Definition
| Early precursor B-cell ALL |
|
|
Term
True or False:
TdT is negative during B-cell ALL |
|
Definition
True
(which is why it's classified separately) |
|
|
Term
| What is B-cell ALL now considered hematologic manifestation of B-cell lymphoma? |
|
Definition
| Because of the TdT being negative |
|
|
Term
| A patient enters the ER with vague malaise. A CBC is ordered and other lab work is ordered as well. The patient shows a decrease in total RBC volume. Rouleaux is seen on peripheral smear. Bence Jones protein tests positive and the ESR is elevated. What disease is likely present? |
|
Definition
|
|
Term
| What is the most common cause of death from multiple myeloma and why? |
|
Definition
| Infection because of the decreased WBC |
|
|
Term
| A positive cryoglobulin test along with elevated IgM and elevated mast cells is consistent with which disease? |
|
Definition
| Waldenstrom's macrogobulinemia |
|
|
Term
| A serum protein electrophoresis showing hypogammaglobulinemia with broad bands in the beta-gamma region is consistent with which disease? |
|
Definition
|
|
Term
| What is the relationship between Reed Sternberg cells and prognosis of lymphoma? |
|
Definition
| Inverse relationship (more reed sternberg = worse prognosis) |
|
|
Term
| What is the relationship between lymphocytes and lymphoma prognosis? |
|
Definition
| Direct relationship (more lymphs = better prognosis) |
|
|
Term
| Which Rye classification of lymphoma has moderate lymphs with few Reed Sternberg cells in nodules? |
|
Definition
|
|
Term
True or False:
Non-Hodgkin's Lymphoma has 80-85% T-cell origin cells in a lymph node biopsy. |
|
Definition
False
80-85% B-cell origin cells |
|
|
Term
True or False:
Diffuse lymphocyte predominance offers the best prognosis for Non-Hodgkin's Lymphoma |
|
Definition
False
Nodular pattern offers the best prognosis for Non-Hodgkins lymphoma. Diffuse lymphocyte predominance offers the best prognosis for Hodgkin's Lymphoma |
|
|
Term
| What is the relationship between the number of lymphocytes and the prognosis of Non-Hodgkins Lymphoma? |
|
Definition
| Inversely related (higher lymphs = worse prognosis/more aggressive) |
|
|
Term
| Large, bizarre cells with cerebriform nuclei present on peripheral smear defines which syndrome? |
|
Definition
|
|
Term
| Non-Hodgkins lymphoma with mycosis fungoides defines which syndrome? |
|
Definition
|
|
Term
True or False:
CD4 markers are positive in Sezary syndrome. |
|
Definition
|
|
Term
| Which general set of syndromes is characterized by fatigue, fever, and bleeding? |
|
Definition
| Myelodysplastic syndromes |
|
|
Term
| Which syndrome is classified as one or more peripheral blood cytopenias together with prominent maturational abnormalities in the bone marrow? |
|
Definition
| Myelodysplastic syndromes |
|
|
Term
| Which myelodysplastic syndrome contains pelgeroid cells and megaloblastic changes within the bone marrow? |
|
Definition
|
|
Term
True or False:
A high amount of blasts are found in refractory anemia. |
|
Definition
False
Less than 5% blasts are present in the bone marrow |
|
|
Term
True or False:
Refractory anemia shows an increase in WBC's |
|
Definition
|
|
Term
True or False:
Refractory anemia with ringed sideroblasts shows an increase in WBC's. |
|
Definition
False
WBC's are normal to decreased |
|
|
Term
| How does refractory anemia with excess blasts differ from refractory anemia with excess blasts in transformation? |
|
Definition
RAEB - less than 5% blasts in peripheral
RAEBIT - greater than 5% blasts in peripheral |
|
|
Term
True or False:
Myelodysplastic syndromes show ineffective hematopoesis. |
|
Definition
|
|
Term
| What is the median age for somebody w/ myelodysplastic syndromes? |
|
Definition
|
|
Term
| Benzene exposure is a risk factor for which disease? |
|
Definition
| Myelodysplastic syndromes |
|
|
Term
True or False:
Hypergranular platelets is associated with myelodysplastic syndromes. |
|
Definition
False
Hypogranular platelets |
|
|
Term
True or False:
Micromegakaryocytes are associated with myelodysplastic syndromes. |
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Definition
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Term
| In myelodysplastic syndromes how could you describe Type 1 blasts, type 2 blasts, and type 3 blasts. |
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Definition
1 - typical
2 - few primary granules (less than 20)
3 - primary granules 9 greater than 20) |
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Term
| In myelodysplastic syndromes, nuclear-cytoplasmia asynchrony is associated with which condition? |
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Definition
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Term
True or False:
Refractory anemia has normal granulocytes and platelets |
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Definition
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Term
| Which myelodysplastic syndrome is associated with unilineage dysplasia? |
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Definition
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Term
73 year old man
myeloperoxidase +
Sudan black B +
Specific esterase +
N/S esterase +
Tdt - |
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Definition
| Acute myelomonocytic leukemia |
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Term
| What is the morphology associated with t(8;21)? |
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Definition
| AML blasts with pointy Auer rods and hypogranular pmns. Auer rods sometimes persist in PMNs |
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Term
| What is the morphology associated with t(15;17)? |
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Definition
| Promyelocytes with Auer rods, often multiple Auer rods |
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Term
| What is the morphology associated with inv(16)? |
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Definition
| Myelomonocytic leukemia with abnormal hybrid eosinophils |
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Term
| What is the morphology associated with PML/RARA? |
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Definition
| Promyelocytes with Auer rods, often multiple Auer rods |
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Term
| Myelomonocytic leukemia with abnormal hybrid eosinophils is associated with which cytogenetic abnormality? |
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Definition
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Term
| Promyelocytes with Auer rods, often multiple Auer rods is associated with which cytogenetic abnormality? |
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Definition
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Term
| AML blasts with pointy Auer rods and hypogranular pmns. Auer rods sometimes persist in PMNs is associated with which cytogenetic abnormality? |
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Definition
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Term
| Why is it important to identify variant translocations in Promyelocytic Leukemia? |
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Definition
| Promyelocytic leukemia does NOT respond to ATRA in some of the variant translocations |
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