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Adv H 1.5
Glossary FCs
35
Biology
Not Applicable
10/20/2021

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Term
Cytoskeleton
Definition
Microscopic network or protein filaments and tubules in the cytoplasm that support cell shape and function
Term
Actin
Definition
A type of protein microfilament in the cytoskeleton
Term
Tubulin
Definition
Type of protein that forms microtubules in the cytoskeleton
Term
Polymerisation
Definition
Process that is involved in the formation of microtubules
Term
depolymerisation
Definition
Process that is involved in the breakdown of microtubules
Term
microtubules
Definition
Hollow structures that form part of the cytoskeleton and spindle fibres
Term
Microtubule Organising Centre (MTOC)
Definition
Structure from where the microtubules originate (also called the centrosome)
Term
Interphase
Definition
Part of the cell cycle between mitotic phases
Term
G1, S, G2
Definition
The three phases of interphase
Term
G1
Definition
First growth phase of interphase
Term
S phase
Definition
Phase of interphase where DNA replication occurs
Term
G2
Definition
Second growth phase of interphase
Term
Mitosis and Cytokinesis
Definition
Two phases of mitotic phase
Term
P, M, A, T
Definition
The order of the four stages of mitosis
Term
Prophase
Definition
Phase of mitosis when the chromosomes condense
Term
Metaphase
Definition
Phase of mitosis when the chromosomes align on the equator
Term
Anaphase
Definition
Phase of mitosis when the chromatids are pulled apart by the depolymerisation of spindle tubules
Term
Telophase
Definition
Phase of mitosis when the two nuclei reform round the decondensed chromosomes
Term
Centromere
Definition
Specialised sequence of DNA that links sister chromatids
Term
Kinetochores
Definition
A complex of proteins associated with the centromere to which the microtubules of the spindle attach
Term
Spindle fibres
Definition
Microtubules to which the chromosomes are attached by kinetochores during cell division
Term
Cytokinesis
Definition
Division of cytoplasm to form two daughter cells
Term
cyclin
Definition
Proteins that control the progression of the cell cycle by activating CDK enzymes
Term
Cyclin-dependant kinases (CDKs)
Definition
When activated by cyclin. cause the phosphorylation of proteins which stimulates the cell cycle
Term
Retinoblastoma
Definition
Tumour suppressor protein, when phosphorylated allows DNA replication in the S phase
Term
G1 CDK
Definition
Inhibits retinoblastoma, allows cell to progress form G1 to S phase
Term
p53
Definition
Tumour suppressor protein activated by DNA damage
Term
Stimulate DNA repair, arrest cell cycle, cause cell death
Definition
Three possible effects of activated p53 protein
Term
G2 checkpoint
Definition
Checkpoint involving p53
Term
Degenerative disease
Definition
Effect of reduction in the rate of the cell cycle
Term
Tumour formation
Definition
Effect of increase in the rate of the cell cycle
Term
Metaphase checkpoint
Definition
Stage when the alignment of chromosomes on the metaphase plate is checked
Term
Proto-oncogene
Definition
Normal gene usually involved in the control of the cell growth or division, which can mutate to form a tumour-promoting oncogene
Term
apoptosis
Definition
Programmed cell death that can be triggered by external or internal cell death signals
Term
Caspases
Definition
Protease enzymes that cause cell destruction
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