Term
|
Definition
| pilocytic - never progresses |
|
|
Term
|
Definition
| Diffuse, cannot be resected, WILL PROGRESS |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Glioblastoma (multiforme is MOST COMMON adult primary brain tumor) |
|
|
Term
|
Definition
| Rare, slow growing; presents with seizure, headache and LOC; often frontal |
|
|
Term
|
Definition
| positive prognostic indicator for oligodendroma |
|
|
Term
|
Definition
| Second most common adult primary tumor; parasagittal or convexities of hemispheres; solid; usually grade I and cured with resection; grade III is malignant |
|
|
Term
|
Definition
| PNS, benign, slow growing and resectable due to encapsulation |
|
|
Term
|
Definition
| Third most common type of adult primary brain tumor |
|
|
Term
|
Definition
| Neuroma that is part of the nerve, high potential for malignancy |
|
|
Term
|
Definition
| Neuromas that happen in 20-30 yr olds around the septum pellucidum |
|
|
Term
|
Definition
| Elderly/immunocompromised; high grade B cell lymphoma with CD20; perivascular and invasive growth pattern |
|
|
Term
|
Definition
| Usually are gliomas (ependymomas - resectable and astrocytomas - diffuse); Can also be a meningioma that infiltrates spinal cord dura |
|
|
Term
| Most common brain metastases |
|
Definition
| Lung, breast, melanoma (80% of brain cancer) |
|
|
Term
|
Definition
| Low grade = younger, High grade = older |
|
|
Term
|
Definition
| hyperintense, highlights edema |
|
|
Term
|
Definition
|
|
Term
| Radiologic findings of II and III Astrocytomas (Glioblastomas) |
|
Definition
| Breakdown of BBB --> more contrast enhancement, tumors are diffuse and poorly circumscribed |
|
|
Term
| Radiologic findings of glioblastoma (glioma) |
|
Definition
| Ring enhancing mass lesions with central necrosis, can cross the midline via the corpus callosum |
|
|
Term
| Radiologic features of oligodendrocytomas (glioma) |
|
Definition
| Slow growing = calcification and hyperintensity |
|
|
Term
| Radiologic features of meningioma (extra-axial) |
|
Definition
| Subarachnoid space, pushes against dura to form a dural tail |
|
|
Term
| Radiological features of schwannoma |
|
Definition
| Hyperintense, usually along the cerebello-pontine angle; most common along CN VIII |
|
|
Term
| Radiological features of central neurocytoma |
|
Definition
| Along septum pellucidum, within lateral ventricles |
|
|
Term
| Radiological features of primary CNS lymphoma |
|
Definition
| Look like metastatic carcinoma or glioblastoma |
|
|
Term
| Histopathology of metastasis |
|
Definition
| Large, darkly staining pleiomorphic cells |
|
|
Term
| Markers that determine melanoma cancer is the origin of metastasis |
|
Definition
| S-100, HMB-25, Melan-A, MITF |
|
|
Term
| Markers that indicate metastasis is breast in origin |
|
Definition
|
|
Term
| Marker that indicates metastasis is lung in origin |
|
Definition
|
|
Term
| Histopathology of grade II and III astrocytoma |
|
Definition
| Long oval nuclei, individual cells infiltrate the neurophil, higher grade = higher cellularity |
|
|
Term
| HIstopathology of glioblastoma |
|
Definition
| Vessel infiltration, pseudo-palisading pleiomorphic tumor cells with central necrosis |
|
|
Term
| Histopathology of oligodendrocytoma grade II |
|
Definition
| Fried egg appearance, perinuclear halos |
|
|
Term
| Histopathology of meningioma |
|
Definition
| Whorls and then calcification into psamomma bodies with time |
|
|
Term
| Histopathology of schwannoma |
|
Definition
| Slow growing, well-encapsulated; hyper and hypocellularity; NO NECROSIS |
|
|
Term
| Histopathology of neurofibroma |
|
Definition
| Intrinsic to the nerve; high amounts of collagen and the propensity to become malignant |
|
|
Term
| Histopathology of central neurocytoma |
|
Definition
| Stains for synaptophysin; round and regular nuclei |
|
|
Term
| Histopathology of primary CNS lymphoma |
|
Definition
| Perivascular, stains for CD20 |
|
|
Term
| Histopathology of ependymoma |
|
Definition
| Canal-like arrangements and peri-vasccular pseudo-rosettes |
|
|
Term
| Genetic syndromes that result in CNS tumors |
|
Definition
| Sturge Webber, tuberous sclerosis, NF I and II, von Hippel Lindau |
|
|
