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Adrenocorticosteroids
Pharmacology
26
Medical
Professional
11/06/2011

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Cards

Term
what secretes epinephrine
Definition
adrenal medulla
Term
what is the rate limiting steps of steroid production?
Definition
conversion to pregnenolone
Term
what is the % of cortisol bound to globulin
Definition
90%
Term
where is cortisol metabolized
Definition
liver
Term
how is ACTH regulated?
Definition
AC-->cAMP-->PKA
Term
func. of ACTH
Definition
fasic and retic growth
increased transport of cholesterol
conversion of choles to pregn
Term
why is prednisone given?
Definition
used as a glucocorticoid, together w/MC deficiency
Term
this inhibits production of cortisol
Definition
Metyrapone
Term
what should be given to pts following long term adrenal suppression?
Definition
hydrocortisone or prednisone
Term
what drug diagnoses Cushing's?
Definition
Dexamethasone
Term
Which GC drugs are more potent and longer lasting
Definition
Betamethasone and dexamethasone
Term
These topical drugs have minimal systemic effects
Definition
Beclomethasone, flunisolide, and memetasone
Term
how can adrenal insufficiency be diagnosed?
Definition
measuring plasma cortisol after admin of ACTH
Term
What is the treatment regimen for Addison's Dz
Definition
Oral hydrocortisone
Fludrocortisone
Term
Which GC is more toxic, Mitotane or Amphenone B?
Definition
Amphenone B
Term
This drug blocks conversion of cholesterol to pregnelone
Definition
Aminoglutethimide
Term
This drug blocks 11-hydroxylation
Definition
Metyrapone
Term
This drug is used to promote spontaneous abortion
Definition
Mifepristone
Term
What is Conn's syndrome?
Definition
excess secretion of aldosterone
Term
Which MC antag has fewer side effects
Definition
eplerenome
Term
This MC antag acts on androgen receptors also
Definition
Spironactalone
Term
How is the MC receptor specified?
Definition
conversion of GC to cortisone by 11-Beta hydroxysteroid dehydrogenase
Term
This is the most common synthetic MC
Definition
Fludrocortisone
Term
This MC agonist is naturally produced in the zona fasiculata
Definition
Desoxycorticosterone
Term
This antifungal serves as a non-selective inhibitor of steroid synthesis
Definition
Ketoconazole
Term
What is the order of antagonization for Mifepristone
Definition
progesterone, GC, and sex steroids
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