Term
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Definition
Class: alpha blocker
Mechanism: nonselective competitive alpha antagonist
Indication: phemochromocytoma
Adverse effects: excess cardiac stimulation (dec. autofeedback alpha2) |
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Term
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Definition
Class: alpha blocker
Mechanism: nonselective irreversible alpha antagonist
Indication: pheochromocytoma
Adverse effect: excess cardiac stimulation (dec. autofeedback alpha2) |
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Term
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Definition
Class: alpha blocker
Mechanism: alpha1 selective competitive antagonist, decreases TVR via dec. sympathetic input to SMCs
Indication: HTN, CHF, BPH
Adverse effect: first dose phenomenon (hypotension/syncope) |
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Term
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Definition
Class: alpha blocker
Mechanism: alpha1 selective competitive antagonist, dec. TVR via dec. sympathetic to SMCs
Indication: HTN, CHF, BPH
Adverse effects: first dose phenomenon (hypotension/syncope) |
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Term
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Definition
Class: alpha blocker
Mechanism: alpha1 selective competitive antagonist, bladder selective (relaxes SMC of bladder neck, prostate capsule, and prostatic urethra)
Indication: BPH
Adverse effects: ejaculatory dysfunction, less hypotension that prazosin |
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Term
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Definition
Class: beta agonist
Mechanism: beta1 and beta2 agonist
Indication: few (generally other adrenergics are better)
Adverse effects: cardiac arrhythmias (inc. mortality) |
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Term
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Definition
Class: beta agonist
Mechanism SHORT-ACTING beta2 selective agonist
Indication: asthma (rescue therapy), COPD; 1ST LINE FOR ACUTE ASTHMATIC BRONCHOSPASM
Adverse effects: potential for CV effects; tremors, duration only 3-4hrs |
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Term
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Definition
Class: beta agonist
Mechanism: SHORT-ACTING beta2 selective, (relax bronchial and uterine SMC)
Indication: rescue therapy asthma, (unlabeled: prevent preterm labor)
Adverse effects: CV effects potentially, tremors;
NO LONGER THAN 48-72HRS IN PREGNANCY, MONITOR BOTH HEART BEATS |
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Term
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Definition
Class: beta agonist
Mechanism: LONG-ACTING beta2 agonist
Indicataion: asthma prophylaxis (NEVER ALONE, use with corticosteroids)
Adverse effects: inc. asthma-related deaths when monotherapy, |
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Term
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Definition
Class: beta agonist
Mechanism: B3 selective agonist, relaxes detrusor SMC during urine storage (inc. capacity)
Indication: overactive bladder
Adverse effects: HTN, slow onset (up to 8wks) |
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Term
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Definition
Class: antimuscarinic
Mechanism: nonselective muscarinic antagonist, therapeutically action selective for bladder (dec. detrusor muscle tone, increase bladder capacity)
Indication: overactive bladder
Adverse effects: typical anticholinergic effects (much lower than other antimuscarinics) |
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Term
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Definition
Class: antimuscarinic
Mechanism: M3 selective antagonist
Indication: overactive bladder
Adverse effects: (less constipation, less confusion), dry mouth and constipation most common |
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Term
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Definition
Class: antimuscarinic
Mechanism: nonselective muscarinic antagonist similar to atropine
Indication: COPD and sometimes for asthma
Advere effects: few b/c poor absorption; toxic dose - hypotension (ganglia blocked), muscle weakness (NMJ block) |
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Term
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Definition
Class: antitussive
Mechanism: NMDA receptor antagnoist, ?? other binding sites; D-isomer of mehtorphan (analog of codeine)
Indication: cough
Adverse effects: nothing really, @ high dose-tachycardia, agitation, pyschosis, seizure, ataxia, coma; abuse potential
PROHIBITED IN CHILDREN <6y/o |
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Term
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Definition
Class: antitussive
Mechanism: irritate gastric mucosa and gastric nerve to stimulate cough reflex, stimulate resp. tract secretions to increase resp. fluid volumes and decrease mucous viscosity
Indication: expectorant
Adverse effects: few |
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Term
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Definition
Class: beta agonist
Mechanism: stimulates all alpha and beta receptors
Indication: treat bronchospasms, bronchial asthma, viral croup, anaphylactic rxns
Adverse effects: nonselective alpha and beta activation (tachycardia, arrhythmias, anxiety, tremors); low bioavailability |
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Term
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Definition
Class: antitussive
Mechanism: agonist at mu opioid receptor, ?? mechanism for antitussive
Indication: mild-moderate pain (esp. combined with aspirin/acetaminophen), ANTITUSSIVE, antidiarrheal
Adverse effects: constipation, respiratory depression (RARE) |
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