Term
| What is the MOA of adrenergic neurotransmission? |
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Definition
| Tyrosine enters and is reduced by Tyrosine hydroxylase to Dopa; Dopa is converted to Dopamine which is then converted to NE and stored in vessicles until released into the synapse. |
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Term
| What is the MOA for terminating the effect of NE? |
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Definition
Combination of reuptake and enyzmatic degredation.
*NET (NE transporter) reuptake
*MAO (monoamine oxyidase) degredation |
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Term
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Definition
1. catechol
2. phenylethylamine
3. norepinephrine
4. epinephrine
5. isoproterenol
6. dopamine |
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Term
| A cocaine of a tricyclic antidepressant would be classified as an ___. Why? |
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Definition
*indirect working agonist
*because it will bind to the NE reuptake transporter thus increase the amount of NE remaining available in the synapse |
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Term
| Epinephrine is a hormone from the ___. |
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Definition
Adrenal medula.
It lacks a methyl group that NE has. |
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Term
| Alpha and Beta receptors are all ___ receptors. |
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Definition
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Term
| What is the typical location of the Alpha 1 receptor? What are the subtypes? |
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Definition
*post-synaptic effector cells of most vascular smooth muscle; puliary dilator muscle; protate
* 1A, 1B, 1D |
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Term
| What is the result of ligand binding/action of the Alpha 1 receptor? |
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Definition
| *increase in intracellular Ca2+, vasoconstriction; contraction |
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Term
| What is the typical location of the Alpha 2 receptor? What are the subtypes? |
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Definition
*post-synaptic receptors in CNS, adrenergic nerve terminals
* 2A, 2B, 2C |
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Term
| What is the result of ligand binding/action of the Alpha 2 receptor? |
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Definition
*inhibition of adenylate cyclase; *decrease in cAMP/opens K+ channel/inhibition of neurotransmitter release
*stimulation produces autoregulatory effect in terms of regulating the activity of simpathetic outflow
*inhibits stimulation of simpathetic outflow
*inhibit by hyperpolarizing |
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Term
| What is the typical location of the Beta 1 receptor? |
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Definition
| *heart, juxtablomerular cells, lipocytes, CNS, ciliary body |
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Term
| What is the result of ligand binding/action of the Beta 1 receptor? |
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Definition
*stimulation of the adenylate cyclase; increase in cAMP/Positive chronotropy and inotropy; renin release
*increase heart rate and force of contraction thus combined leads to increaesed cardiac output. |
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Term
| What does cardiac output depend on? |
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Definition
| stroke volume and heart rate |
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Term
| What is the typical location of Beta 2 receptors? |
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Definition
*respiratory uterine and vascular smooth muscle
*mainly present in areteries going to skeletal muscle as opposed to vascular smooth muscle in the Alpha 1 |
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Term
| What is the result of ligand binding/action of the Beta 2 receptor? |
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Definition
*vaso dilation of the arteries going to skeletal muscle
*stimulation of adenylate cyclase; increase in cAMP/smooth muscle relaxation |
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Term
| What is the typical location of the D1(dopamine 1) receptor? |
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Definition
| *renal, mesenteric, coronary and cerebral blood vessels |
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Term
| What is the result of ligand binding/action of the D1 receptor? |
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Definition
*vasodilation of renal arteries with increase in blood flow and filtration rate (promotes excretion of fluids)
*inhibition of NA/H pump |
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Term
| What is the typical location of D2 (dopamine 2) receptor? |
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Definition
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Term
| What is the result of ligand binding/action of the D2 receptor? |
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Definition
| *inhibition of adenylate cyclase; decreasein cAMP; modulates neurotransmitter release |
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Term
| How do A2 and B signaling oppose each other? |
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Definition
| *A2 inhibits adenylate cyclase and B1 stimulates it |
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Term
| What are the classes of adrenergic agaonists? |
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Definition
1. direct acting
2. mixed acting
3. indirect-acting |
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Term
| What are the classes of indirect-acting Adrenergic Agonists? |
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Definition
1. releaseing agents
2. utake inhibitor
3. MAO/COMT inhibitors |
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Term
| What are the classes of Direct Acting Adrenergic Agonists? |
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Definition
1. Secective
2. Non-selective |
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