Term
| catecholamines what are they |
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Definition
| dopamine, norepinephrine, ephineprhine |
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Term
| syntehtsis fo cateacholamines |
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Definition
| tyrosine via tyrosine hydroxylase to dopa via dopa decarboxylase to dopamine via dopamine b hydroxylase to norepeinenrpiherine |
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Term
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Definition
| most celeared via norepinerphinre transported which transports to presynaptic cell. Some trnasported to post synatpic cell via ENT (extraneuronal trnasporter) or OCT 3 (organic cation transporter 3) . Rest diffusesi nto circulation . |
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Term
| catechoalmine metabolizesr |
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Definition
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Term
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Definition
| mitochondrial otuerm embrane |
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Term
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Definition
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Term
| net effect of catecholamien post release |
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Definition
| most is reuptaken via net, and transported to storage vesicelsdue to higher affinity to vmat-2 than mao. |
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Term
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Definition
| inhibits tyrosine hydroxylase and catecholamien syntehsis |
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Term
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Definition
| blocks storage in vsicles |
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Term
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Definition
| blocks transmitter release |
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Term
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Definition
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Term
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Definition
| indirect agonists which promote transmitter releasse |
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Term
| cocaine, tricicylic antidepressants |
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Definition
| block transmitter reuptake |
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Term
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Definition
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Term
| beta catecholamine receptor coupling |
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Definition
| Gs positive instigation fo adencyl cyclaste wich increase camp and goesto PKA |
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Term
| alpha 2 recpetor copuglign |
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Definition
| geos to Gi which inhbiits adenyl cyclase which decrease camp which decreases PKA |
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Term
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Definition
| goes to Gq which goes to DAg increasing protein kinase c levels, and also geos to PIP2 and IP3 increasing calcium levels |
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Term
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Definition
increase in camp promotes relaxation of smooth muscle.
on cardiac muscle: Beta Gs icnreases camp and promotes rate of caclium reuptake - increaasign contraction and increased chronotropic and ionotropic effects |
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Term
| alpha 2 downstream effects |
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Definition
| smooth muscle: will decrease cam pand cauase contraction - vasoconstriaction |
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Term
| alpha 1 downstream effects on smooth muscle |
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Definition
| will cause vasoconstriciton , due to increased calcium |
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