Shared Flashcard Set

Details

Adrenergic drugs
N/A
69
Other
Graduate
05/23/2009

Additional Other Flashcards

 


 

Cards

Term
Dopamine
Definition
Monoamine neuro transmittreer. inhibits prolactin secretion. acts on D1 and D2 receptors. high levels promote schizophrenia and low levels promote parkinsonism. increases libido
Term
GABA
Definition
Amino acid based neurotransmitter. inhibitory actions in CNS works on chloride channels
Term
Glutamate
Definition
Amino acid based neurotransmitter. Excitatory in CNS works on sodium channels
Term
Glycine
Definition
Amino acid based neurotransmitter. increases affinity of glutamate for its receptor. inhibitory in spinal cord prevents over stimulation.
Term
Anandamide
Definition
lipid based CNS neurotransmitter. reduces anxiety, elevates mood, stimulates appetite, invovled in motor coordination. inperiphery stimulates fat accumulation. helps with embryo implantaion in uterus
Term
Metyrosine
Definition
inhibits tyrosine hydroxylase (the enzyme that converts tyrosine to DOPA). used in the treatment of a pheochromcytoma
Term
Carbidopa
Definition
inhibits L-aromatic amino acid decarboxylase(DOPA decarboxylase) preventing the formation of Dopamine from DOPA. Used in conjunction with L-DOPA to treat Parkinson's symptoms. Carbidopa does not cross the BBB but L-DOPA does.
Term
Entacapone
Definition
inhibits COMT preventing the metabolism of L-DOPA to 3-O-MD in the periphery. also used in treatment of Parkison's disease.
Term
Disulfiram
Definition
inhibits dopamine-beta-hydoxylase and prevents conversion of dopamin to NE. used in treatment of alcoholism. this drug chelates copper and effects acetyl dehydrogenase thereby increasing the feeling of a hangover after ingesting small amounts of alcohol.
Term
Reserpine
Definition
prevents uptake of NE and dopamine into synaptic vesicles in nerve varicosities. less NE in vesicle leads to less release in cleft. used for treament of HTN and psychosis. also damages vesicles creating a chemical sympathectomy by also decreasing levels of E and Serotonin.
Term
L-DOPS
Definition
drug that is converted to NE by DOPA decarboxylase. used in treatment of familial dysautonomia (deficiency in dopamine-beta-hydroxylase)
Term
alpha-methyldopa
Definition
precursor of NE that can cross BBB. used in treatment of HTN. alpha-methylnorepinephrine is a false neurotransmittter that causes vasonconstriction in periphery but its action on alpha 2 receptor in RVLM in brain reducing impulses to release NE and false neurotransmitter decreasing BP.
Term
Botulinum Toxin
Definition
contains proteases that degrade the proteins involved in exocytosis of NE containing synaptic vesicles. degrade synaptobrevin, syntaxin, and SNAP-25
Term
Bretylium Tosylate
Definition
initial NE release followed by blocking of exocytosis and inhibition of NE release. used in critical cardiac care in unresponsive arrythmias.
Term
Isoprotenol
Definition
beta 1 and 2 receptor agonist that cannot be taken up by amine pump transporter in nerver terminal.
Term
Cocaine
Definition
blocks amine pump transporter  and inhibits reuptake of NE, E, and dopamine by presynaptic neuron. results in more NE in cleft
Term
Amphetamine/Tyramine
Definition
drug that is taken up by amine pump transporter and displaces NE in synaptic vesicles causing NE to be displaced into the clefts. does not require an AP to release NE. is an indirect sympathomimetic
Term
Epinephrine
Definition
sympathomimetic acting on alpha 1 and 2 and beta 1 and 2 receptors
Term
Norepinephrine
Definition
sympathomimetic that acts on alpha 1 and 2 and beta 1 receptors.
Term
Phenylephrine
Definition
sympathomimetic that acts on alpha 1 receptor only.
Term
Methoxamine
Definition
sympathomimetic that acts only on alpha 1 receptor.
Term
Clonidine
Definition
Sympathomimetic that acts on alpha 2 receptor.
Term
Guanabenz
Definition
Sympathomimetic that acts on alpha 2 receptor
Term
Dobutamine
Definition
sympathomimetic that acts on beta 1 receptor primarily and at high doses stimulates beta 2 and alpha 1 receptors
Term
Metaproterenol
Definition
direct acting beta 2 adrenergic agonist
Term
Terbutaline
Definition
direct acting beta 2 adrenergic agonist
Term
Albuterol
Definition
direct acting beta 2 adrenergic agonist
Term
Bitolterol
Definition
direct acting beta 2 adrenergic agonist
Term
Salmeterol
Definition
direct acting beta 2 adrenergic agonist. has a longer duration of action
Term
Formoterol
Definition
direct acting beta 2 adrenergic agonist. has a longer duration of action
Term
TCA e.g. Desipramine and Amitryptyline
Definition
inhibit neuronal uptake of NE. Tx: depression
Term
Tranylcypromine
Definition
MAO-a and b inhibitor. used for treatment of depression and panic disorders.
Term
Phenelzine
Definition
MAO-a and b inhibitor. used for treatment of depression and panic disorders.
Term
Selegiline
Definition
MAO-b inhibitor. used in treatment of parkison's to reduce L-DOPA degradation
Term
Phentolamine
Definition
anatgonist the blocks alpha 1 and 2 receptors
Term
Phenoxybenzamine
Definition
anatgonist the blocks alpha 1 and 2 receptors. long lasting effects
Term
Prazosin
Definition
alpha 1 antagonist only
Term
Terazosin
Definition
alpha 1 antagonist only
Term
Trimazocin
Definition
alpha 1 antagonist only
Term
Doxazosin
Definition
alpha 1 antagonist only
Term
Rauwolscine
Definition
alpha 2 antagonist only
Term
Pindolol
Definition
nonselective beta 1 and 2 anatgonist with low lipid solubility
Term
Nadolol
Definition
nonselective beta 1 and 2 anatgonist with low lipid solubility
Term
Timolol
Definition
nonselective beta 1 and 2 anatgonist with low-moderate lipid solubility
Term
Propanolol
Definition
nonselective beta 1 and 2 anatgonist with high lipid solubility
Term
Penbutolol
Definition
nonselective beta 1 and 2 anatgonist with high lipid solubility
Term
Acebutolol
Definition
beta 1 antagonist with low lipid solubility
Term
Atenolol
Definition
beta 1 antagonist with low lipid solubility
Term
Metoprolol
Definition
beta 1 antagonist with moderate lipid solubility
Term
Carvedilol
Definition
beta 1 and 2 and alpha 1 antagonistwith moderate lipid solubility
Term
Labetalol
Definition
beta 1 and 2 and alpha 1 antagonist with low lipid solubility
Term
Butoxamine
Definition
not approved beta 2 antagonist
Term
diphenhydramine
Definition
histamine receptor antagonist
Term
alpha 1 receptor actions at post junction
Definition

vasoconstriction of blood vessels

decreased GI motility and tone

Stimulation of glycogenlysis

Contraction of sphincter muscle in GI and bladder, and radial muscle in eye

Term
alpha 2 receptor actions at post junction
Definition

vasoconstriction of blood vessels

Hypotension RVLM

Decreased GI motility and tone

Inhibition of insulin release pancreas

Fat cell lipolysis

Platelet aggregation

Term
beta 1 post junctional response
Definition

cardiac stimulation of heart

Decreased GI motility and tone

Adipose tissue fatty acid mobilization

Increased Renin release kidney

Term
beta 2 post junctional response
Definition

Dilation of arteries and veins, Decreased GI motility and tone, Increased insulin secretion pancreas, Glycogenolysis and gluconeogenesis liver and muscle, Increased glucagon secretion

Relaxation of bronchial smooth muscle and bladder detrusser and pregnant uterus

Term
pre-junctional adrenergic alpha 2 response
Definition

inhibition of NE release from adrenergic nerves

Inhibition of Ach release from parasympathetic nerve

Inhibition of serotonin

inhibition of dopamine release in brain

Term
pre-junctional adrenergic beta 2 response
Definition
increase NE release from adrenergic nerves
Term
Apomorphine
Definition
D1 and D2 agonist
Term
Dopamine
Definition
D1 and D2 agonists
Term
Fenoldopam
Definition
D1 agonist
Term
Bromocriptine
Definition
D2 agonist
Term
post junctional D1 response
Definition
vascular relaxation in renal and mesenteric blood vessels, Natriuresis and diuresis in kidney, Stimulation of parathyroid hormone release
Term
post junctional D2 response
Definition
inhibition of prolactin release
Term
Pre junctional D2 response
Definition

inhibition of NE release from adrenergic nerves

Inhibition of Dopamine release from from dopaminergic nerve and CNS

Term
ephedrine
Definition
direct alpha 1 and beta 2 agonist also has indirect actions
Term
metaraminol
Definition
direct alpha 1 agonist also has indirect actions
Term
Haloperidol
Definition
D1 and D2 antagonist used for psychogenic disorders
Supporting users have an ad free experience!