Term
|
Definition
potent, reversible, competitive
non-selective a antagonist |
|
|
Term
|
Definition
short duration
hypertensive crisis
phaeochromocytoma surgery |
|
|
Term
|
Definition
block A1= decrease peripheral vasc R, causes reflex tachycardia
block A2= increased NE and exacerbates reflex tachycardia
increases CO and HR with no effect on BP |
|
|
Term
|
Definition
can inhibit serotonin receptors
activate muscarinic and histaminergic receptors |
|
|
Term
|
Definition
| adverse effects: severe tachycardia, arrhythmia, myocardial ischemia, nasal congestion, headache |
|
|
Term
|
Definition
irreversible
a1 > a2 slightly |
|
|
Term
|
Definition
increases blood flow to skin, mucosa, and abdominal organs
lowers supine and erect blood pressure |
|
|
Term
|
Definition
| useful in tx HTN from pheochromocytoma (symptoms such as HTN and sweating, or pre-op for removal with large amount of catecholamine release) |
|
|
Term
PRAzosin
TERAzosin
DOXAzosin |
|
Definition
reversible
highly selective a1 |
|
|
Term
PRAzosin
TERAzosin
DOXAzosin |
|
Definition
tx HTN in Raynaud's syndrome and urinary obstruction BPH
(less reflex HTN) |
|
|
Term
PRAzosin
TERAzosin
DOXAzosin |
|
Definition
| can reduce preload and afterload to improve CO in patients with heart failure |
|
|
Term
PRAzosin
TERAzosin
DOXAzosin |
|
Definition
intiial tx can cause dramatic postural hypotension
alleviated by slow administration |
|
|
Term
PRAzosin
TERAzosin
DOXAzosin |
|
Definition
| more common adverse effects include dizziness, drowsiness, headache, lack of energy, nausea, and palpitations |
|
|
Term
|
Definition
a1 selective
metabolized in liver
higher potency for helping BPH (inhibiting prostate smooth muscle contration), but produces less hypotension |
|
|
Term
|
Definition
| preferred for treating BPH in patients with hypotension |
|
|
Term
|
Definition
a2 selective antagonist
alkaloid
no clinical use, but can technically increase transmitter release
antidiuretic
might improve male sexual performance |
|
|
Term
|
Definition
| pirmary HTN and benign prostatic hyperplasia |
|
|
Term
| non-selective a antagonists |
|
Definition
|
|
Term
| tamsulosin, prazosin, terazosin, doxazosin |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| rauwolscine, yohimbine, tolazoline |
|
Definition
|
|
Term
|
Definition
| adverse effects: postural hypotension, tachycardia, nasal stuffiness, sexual dysfunction, fatique, sedation, nausea |
|
|
