Term
| Uses of alpha receptor antagonists |
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Definition
- pheochromocytoma (phentolamine/phenoxybenzamine)
- chronic hypertension (prazosin, doxazosin, terazosin)
- urinary retention in benign prostatic hyperplasia (prazosin, doxazosin, terazosin, tamsulosin)
- erectile dysfunction (yohimbine) |
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Term
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Definition
- alpha receptor antagonists
- reversible
- used for hypertensive crisis |
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Term
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Definition
- alpha receptor antagonists
- irreversible |
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Term
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Definition
- alpha receptor antagonist (1>>>>2)
- reversible |
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Term
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Definition
- alpha receptor antagonist (1>>>>2)
- reversible |
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Term
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Definition
- alpha receptor antagonist (1>>>>2)
- reversible |
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Term
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Definition
- alpha receptor antagonist
- reversible
- 1>2
- used for BPH, urinary retention |
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Term
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Definition
- alpha receptor antagonist (2>>>1)
- reversible
- used pro prevent ejaculation and prolong erection
- worry about SE |
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Term
| Adverse SE of alpha blockers |
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Definition
- postural hypotension
- reflex tachycardia (because NE will activate B receptors)
- N/V
- dizziness
- nasal stuffiness
- sexual dysfunction |
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Term
| Effects of beta blockers on heart |
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Definition
- Depress SA and AV activity
- work on cardiac muscle, reducing cardiac output, work, and O2 consumption
- so you get decreased HR and contractility
- bad news bears for people who exercise a lot |
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Term
| Effects of beta blockers on blood vessels |
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Definition
- inhibition of B2 recepors on vessels in mm blocks vasodilation
- inhibition of B2 receptors on skin and organs causes reflex vasoconstriction because alpha1 now unopposed |
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Term
| Effects of beta blockers on kidney |
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Definition
| - inhibit release of renin form JGA, so decrease BP |
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Term
| Effects of beta blockers on respiratory system |
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Definition
- block B2 receptors on bronchial smooth muscle
- can provoke life-threatening bronchoconstriction |
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Term
| Effects of beta blockers on the eye |
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Definition
| - decrease production of aqueous humor from ciliary epithelium |
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Term
| Metabolic and endocrine effects of beta blockers |
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Definition
- inhibit release of glucagon, thus slowing release of glucose into blood
- may cause hypoglycemia
- dangerous with type I diabetes |
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Term
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Definition
- Hypertension (propanolol, metropolol, etc used for mild to moderate HTN; labetalol for pheocrhromocytoma and hypertensive emergencies)
- Ischemic heart disease (reduce frequency of angina pectoris, decreased oxygen demand)
- MI/Cardiac arrhythmias (decrease infarct size)
- congestive heart failure
- glaucoma (timolol- for chronic)
- hyperthyroidism
- migraine
- propranolol for stage fright
- propranolol and metoprolol for postural tremors
- propranolol for symptoms associated with alochol withdrawal |
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Term
| Adverse SE of beta blockers |
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Definition
- bronchoconstriction
- arrhythmias
- contraindication with AV heart block
- fatal reactions with heart disease
- abrupt discontinuation in heart patients is bad
- sexual impairment
- may exacerbate hypoglycemia
- drug interactions |
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Term
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Definition
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Term
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Definition
- beta blocker
- no MSA, so good for glaucoma |
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Term
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Definition
| - beta blocker, but blocks alpha1 too |
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Term
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Definition
- beta blocker, but blocks alpha1 too
- pheochromocytoma |
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Term
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Definition
Alpha blockage can cause a fall in blood pressure
- happens because epi is activating B receptors which dilate, and normally this would be equalled out by epi also activating alpha receptors |
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