Term
| This group of antagonist produces an irreversible blockade |
|
Definition
| haloalkyl amines (phenoxybenzamine) |
|
|
Term
| 2 non selective alpha blockers |
|
Definition
| phentolamine and phenoxybenzamine |
|
|
Term
| These receptors diminish NE release |
|
Definition
|
|
Term
|
Definition
| block alpha 2 receptors to increase NE |
|
|
Term
|
Definition
| prazosin, terazosin, doxazosin, and tamsulosin--> essential hypertension and BPH |
|
|
Term
| This drug may block histamine receptors and reuptake of catecholamines |
|
Definition
|
|
Term
| Action of phenoxybenzamine |
|
Definition
dilates smooth muscle
Increase in heart rate and contractility (incr in NE) |
|
|
Term
| Side effects of phenoxybenzamine |
|
Definition
postural hypotension
tachycardia
failure to ejaculate
drowsiness |
|
|
Term
| Phentolamine mech of action |
|
Definition
reversible comp inhibition at a1 and a2
Blocks serotonin at higher doses |
|
|
Term
|
Definition
same as phenoxybenzamine
releases histamine from mast cells |
|
|
Term
| Phentolamine side effects |
|
Definition
same as phenoxybenzamine
GI motility and secretion |
|
|
Term
| Phentolamine drug contraindications |
|
Definition
| DO NOT give to patients w/gastritis or ulcer |
|
|
Term
| What happens to BP when phentolamine is given prior to Epi? |
|
Definition
| Decrease (B1 +2) yields this effect |
|
|
Term
| Clinical uses of Non selective alpha inhibitors |
|
Definition
Hypertension caused by catecholamine tumors (pheochromocytoma)
Treatment of peripheral vascular disease (vasoconstricted blood vessels)
Inoperable prostatic hypertrophy (decr bladder contraction) |
|
|
Term
| special clinical use of phentolamine |
|
Definition
| dermal necrosis prevention |
|
|
Term
|
Definition
decrease peripheral vascular resistance
vasodilation
decreases cardiac pre-load
increase HDL
does NOT increase tachycardia |
|
|
Term
|
Definition
|
|
Term
| Side effects of A1 inhibitors |
|
Definition
|
|
Term
| These are more water soluble analogs of Prazosin |
|
Definition
Terazosin, Doxazosin
Longer halflife |
|
|
Term
|
Definition
| BPH w/little effect on BP |
|
|
Term
|
Definition
|
|
Term
| B-blocker mech. of action |
|
Definition
rev. comp antag
partial agonist activity
local anesthetic effect
B-1--> for Asthma patients |
|
|
Term
| what are the non selective beta blockers? |
|
Definition
propanolol
nadolol (longest half-life)
timolol
pindolol (partial agonist, local anesth) |
|
|
Term
|
Definition
Atenolol
Esmolol (short half life; IV use)
Metoprolol
Acebutolol (part agonist, anestethic) |
|
|
Term
| Mixed Blockers (B1,2, A1) |
|
Definition
Labetaolol (B2 part agonist)
Carvedilol (Only blocks A1) antioxidant good in CHF patients |
|
|
Term
| Beta blockers pharm action |
|
Definition
decr heart rate
myocardial contractility and CO
Acute incr in TPR
decr. blood flow
incr. airway resistance (antag B-2)
reduce intraocular pressure in OPEN angle glaucoma |
|
|
Term
| clinical uses of b-blockers |
|
Definition
hyperthyroidism
open angle glaucom
migraine headaches
acute aortic aneurysm |
|
|
Term
| Beta blocker side effects |
|
Definition
decr HR and CO
decr cond. velocity
bronchoconstriction (not good for COPD)
hypoglycemia- avoid diabetics
rash and fever. |
|
|
Term
| Non-selective beta blocker with partial agonist activity |
|
Definition
|
|
Term
| selective beta blocker w/partial agonist activity |
|
Definition
|
|
Term
| Mixed beta blocker w/partial agonist activity |
|
Definition
|
|
Term
| non-selective B-blocker used in opthalmic treatment |
|
Definition
|
|
