Term
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Definition
| tyrosine --> L-Dopa --> Dopamine --> Norepi --> Epi |
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Term
| Enzymes involved in metabolism |
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Definition
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Term
| Enzymes altering re-uptake |
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Definition
Dopamine Transporter (DAT)
Norepinephrine transporters (NET)- tricyclic antidepressants block this |
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Term
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Definition
| Block reuptake and reverse the transporter- lots of catecholamine release |
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Term
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Definition
- G protein stimulates PLC, making IP3, DAG, and increasing Ca
- primarily located in vessels in skin and gut
- activation causes contraction
- don't need a lot of blood in skin and gut
- also get contraction of: pupillary dilator muscle, heart, GU tract
- Phenylephrine |
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Term
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Definition
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Term
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Definition
- Inhibits AC, decreasing cAMP
- direct opposition to betaAR?
- when applied directly on vessel, it will contract
- if given systemically, CNS sends out negative feedback leading to a decrease in heart rate and blood pressure
- Overall decrease in norepi levels
- peripheral actions: vasoconstriction when topical application, GI decreased secretion and motility, pancrease decreased release of insulin, decreased lipolysis, decreased aqueous humor production
- Clonidine- decreases BP
- oxymetazoline- topically for congestion
- apraclonidine- topically for glaucoma |
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Term
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Definition
- alpha2AR agonist
- for hypertension because it decreases BP |
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Term
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Definition
- alpha2AR agonist
- apply topically for congestion |
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Term
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Definition
- alpha2AR agonist
- apply topically for glaucoma |
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Term
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Definition
- GPCR that stimulates AC to make more cAMP
- heart- stimulates rate and force of contractions
- kidney- stimulates renin release by JGC's, renin increases BP
- dobutamine- increases cardiac output with less reflex tachycardia than non-selective B agonists |
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Term
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Definition
B1AR agonist
- increases cardiac output with less reflex tachycardia than non-selective B agonists |
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Term
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Definition
- GCPR stimulating AC to make cAMP
- bronchi, uterus, bladder- relaxes vascular smooth muscle
- cardiovascular- relaxes peripheral vascular resistance, so increases HR
- skeletal muscle- increases potassium uptake (increasing contraction)
- liver- stimulates glycogenolysis
- pancreatic B cells- stimulates insulin release
- Albuterol (asthma), terbutaline(acute bronchospasm, premature labor), salmeterol (chronic bronchospasm) |
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Term
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Definition
- B2AR agonist
- Use for asthma |
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Term
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Definition
- B2AR agonist
- Use for acute bronchospasm and premature labor |
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Term
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Definition
- B2AR agonist
- chronic bronchospasm |
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Term
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Definition
- least understood, may stimulate lipolysis
- seems to be involved in heart failure
- relaxes detrusor muscles in bladder |
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Term
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Definition
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Term
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Definition
- When GRK comes in and phosphorylates B2 receptor, arrestin comes in and internalizes this receptor
- 2 possible outcomes: 1. resensitization 2. downregulated (not returned to surface) |
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Term
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Definition
| - blocks reuptake of dopamine via DAT |
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