Term
| Dopamine How it works and what it treats |
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Definition
Peripheral D receptors increase blood flow (vasodilation) to renal, mesenteric, coronary, cerebral vascular beds
Preserves vital organs
Treats cardiogenic & hypovolemic shock
Treats CHF |
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Term
Dopamine dosage pattern
Effect on Heart
Effect on Peripheral Resistance |
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Definition
2.5mcg/kg/min just D1 receptors
5 D1 and B1
20-50 D1 B1 a1 (and vasoconstriction)
Dopamine increases inotropy more than HR
Overall vasodilation due to D1 receptor/TPR reduced
B1 activation causes increased systolic |
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Term
| Compare dopamine effects to epinephrine |
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Definition
| both decrease TPR about the same but via different receptors Dopamine does not increase HR as much but does increase MAP unlike epi |
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Term
What is prodrug?
What does Dopa do? |
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Definition
Prodrug has no activity on its own until it gets metabolized to active drug form
Dopa can cross BBB unlike dopamine and then be converted to dopamine in CNS and treat Parkinson's |
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Term
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Definition
a1 agonist
used in surgery to raise BP minimal effect on heart though high [] constrict coronaries
nasal decongestant by decreasing local blood supply in nose |
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Term
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Definition
a2 agonist-reduces sympathetic outflow from CNS
emergency antihypertensive but too many side effects for long term use |
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Term
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Definition
Prodrug, converted to a-methylnorepinephrine; works on a2 presynaptic receptor
antihypertensive of choice in pregnant women. |
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Term
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Definition
selective for B1-Increases Cardiac Output
used in cardiogenic & septic shock and CHF |
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Term
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Definition
fairly selective for B2
used for bronchospasm like albuterol |
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Term
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Definition
Fairly selective B2
relaxes uterus to prevent premature delivery |
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Term
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Definition
enhance local anesthetic via a1
anaphylactic shock via a1 B1 B2 and inhibit mast cell degranul via B2
treat glaucoma via a1 a2 |
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Term
| General side effects of adrenergic agonists |
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Definition
| Raise BP, tachycardia, nervousness, cardiac arrhythmias, hyperglycemia, exaggerated effects with cocaine |
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Term
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Definition
Indirect acting adrenomimetic
causes release of NE
abundant in cheese; contraindicated if on COMT MAO inhibitors |
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Term
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Definition
Indirect acting adrenomimetic
causes release of NE |
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Term
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Definition
Indirect acting adrenomimetic
causes release of NE
#2 drug for ADD/ADHD |
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Term
| imipramine, amitriptyline, fluoxteine, Prozac |
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Definition
first two are tricyclic antidepressants; 2nd 2 are SSRIs
All intended to inhibit reuptake of serotonin and raise its levels in CNS
but also inhibit reuptake of NE leading to tachycardia |
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Term
| alpha 2 selective agonist side effects |
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Definition
| hyperglycemia from reduced insulin secretion |
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Term
| alpha 2 selective agonist side effects |
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Definition
| hyperglycemia from reduced insulin secretion |
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Term
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Definition
Indirect agonist , causes release of NE thus mimicing NE
#1 drug used to treat ADD/ADHD (Ritalin) |
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