Term
| What are the 2 hyperfunction adrenal disorders? |
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Definition
- Cushing's syndrome - ectopic or adrenal tumors cause excess cortisol
- Hyperaldosteronism - hyperplasia or tumors increase aldosterone |
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Term
| What are the 3 hypofunction adrenal disorders? |
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Definition
- Addison's - decreased cortisol caused by autoimmune, infection, or tumor
- AAI - after abrupt steroid discontinuation
- Hypoaldosteronism - tumor or hypopituitary - not enough aldosterone. |
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Term
| What causes Cushing's syndrome? |
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Definition
Steroids
Abnormal adrenal gland
Abnormal adrenocorticoid tissue: pituitary adenoma, ectopic ACTH |
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Term
| How does Cushing's syndrome present? |
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Definition
Increased fat deposition
Increase Blood glucose
Increased volume/blood pressure --> CV disease.
Excess facial hair, decreased healing, increased infection
Osteoporosis and muscle wasting
Increased glaucoma risk |
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Term
| How is Cushing's syndrome treated? |
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Definition
1st line - surgery to remove tumor/source
2nd line - drugs |
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Term
| What is acute adrenal insufficiency/adrenal crisis? |
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Definition
Abrupt continuation of steroids - there is no cortisol due to adrenal atrophy
- Decrease in fluid volume and BP can lead to SHOCK
- N/V, abdominal pain
- Fever, decrease in BG, increase in K+
- Loss of pigmentation
Treatment: Steroids, IV steroids. |
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