Term
| MOA adrenocorticosteroids |
|
Definition
bind to intracellular receptor in target tissues
receptor-hormone complex initiates/inhibits transcription of genes
***slow response*** |
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|
Term
| adrenocorticosteroids react w/ what drugs |
|
Definition
catecholamines-> mediate bronchiolar relaxation
QUICK EFFECTS! |
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|
Term
| Glucocorticoids promote metabolism by |
|
Definition
| favoring gluconeogenesis-> incr uptake of AA by liver, stimulate protein catabolism and lipolysis |
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|
Term
| glucocorticoids increase resistance to stress by |
|
Definition
| raising glucose levels, provide body w/ energy of stress |
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|
Term
| glucocorticoids alter blood cell levels by |
|
Definition
decr eosinophils, basophils, monocytes, lymphocytes-> redistribute them to lymphoid tissue.
incr HgB, RBC, platelets, PMN's |
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|
Term
| glucocorticoids anti-inflamm effects |
|
Definition
lower lyphocytes and macrophages and inhibit phopholipase A-2.
interferes w/ degranulation of mast cells and decr. histamine release and cap permeability |
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|
Term
| hydrocortisone isused to tx |
|
Definition
primary, secondary, and tertiary adrenal insufficiency
|
|
|
Term
| glucocorticoid used for d/o of cushings |
|
Definition
|
|
Term
| glucocorticoids used to tx allergy |
|
Definition
beclomethasone
triamcinolone |
|
|
Term
|
Definition
accelerated lung maturation
replacement for adrenal hyperplasia
reduce inflammation |
|
|
Term
|
Definition
decr immune response
osteoporosis
incr app
cushings->cataracts, hyperglycemia, hypokalemia
emotional disturbances
glaucoma |
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|
Term
| what type of blood protein do steroids bind to |
|
Definition
| globulin (90%) NOT albumin-> less DI's |
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|
Term
| which is the only steriod that does NOT affect fetus |
|
Definition
|
|
Term
| can steroids be withdrawn abruptly? |
|
Definition
NO->can cause acute adrenal insufficiency (lethal)
psych dependence |
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