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Addiction and Concepts
Pharmacotherapy Exam 3
15
Pharmacology
Professional
03/29/2013

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Cards

Term
abuse
Definition
the continued use of drug despite negative consequences
Term
addiction
Definition
compulsion: consumed with the addiction; time spent thinking, getting or using, negative consequences and denial; after going through withdrawal there is tendency for relapse
Term
DSM IV criteria for substance dependance
Definition
Inability, More drug used, a lot of time, tolerance, old activity, friends and family members, withdrawal and negative consequences
Term
behaviors of addiction
Definition
lying, cheating, stealing, irresponsibility, denial, selfishness, lack of caring, outright defiance
Term
pre-frontal cortex
Definition
part that makes us human; planning, motivating action, memory, reward systemand emotion
Term
reward
Definition
goes to prefontal cortex and then to hippocampus
Term
nucleus acumbens (NAcc)
Definition
collection of neurons located in the forebrain
Term
ventral tegmental area
Definition
located in the midbrain atop the brainstem, one of the, very primative
Term
the frontal cortex
Definition
defective in addiction?
Term
mid-brain
Definition
eat for survival, kill to defend, sex, pleasurable/salient
Term
drugs tap into the core system
Definition
these systems evolved to mediate survival
Term
scientific definition of addict
Definition
addiction is a dysregulation of the midbrain dopamine system (pleasure center) resulting in symptoms of decreased brain functioning, specifically: 1. loss of control, 2. craving/ suffering, 3. persistent drug use despite negative consequences
Term
drug DA reinforcement
Definition
5-10 fold higher than those induced by natural reinforces
Term
drug becomes survival
Definition
in addiction and at the level of unconsciousness
Term
D2R2
Definition
allele that is associated with decreased DA receptors in the midbrain but doesn't cause addiction, addicts tend to have higher percentage that have this allele
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