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Adaptive Changes in Metabolism
Medical School Biochemistry
31
Biochemistry
Graduate
09/29/2011

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Term
What is happening to glucose levels during the post-absorptive state?
Definition
Glucose levels drop
Term
If glucose levels are dropping, what hormone is dropping?
Definition
Insulin
Term
If glucose levels are dropping, what hormone is elevating?
Definition
Glucagon
Term
How long do liver stores of Glycogen last?
Definition
About 24 hours
Term
What organ does Glucagon target? What is the function of Glucagon
Definition
Liver. Glucagon stimulates Glycogenolysis and Gluconeogenesis. Even though glycogen is stored in the muscles, it is not affected by this mechanism
Term
What is the normal range for a fasting blood glucose?
Definition
70-100 mg/dcl
Term
What is the cut-off for fasting blood glucose above which the patient would be hyperglycemic?
Definition
Greater than 125 mg/dcl
Term
What is the cut-off for fasting blood glucse, below which the patient would be hypoglycemic?
Definition
Less than 45 mg/dcl
Term
What are the three substrates generated for Gluconeogenesis?
Definition
Lactate, Glycerol, and Alanine
Term
What are the two processes by which the liver generates glucose in the postabsorptive state?
Definition
Gluconeogenesis and Glycogenoysis
Term
What process is going on in the brain in the postabsorptive state?
Definition
Aerobic metabolism of glucose
Term
What process is ongoing in anaerobic tissues such as red blood cells in the post-absorptive state?
Definition
Anaerobic Glycolysis
Term
Gluconeogenesis uses what two substrates to yield glucose?
Definition
Phosphorylated Glycerol and Pyruvate
Term
What is Glycogenolysis?
Definition
The process in the liver in which glycogen is broken down into glucose
Term
What are the sources of pyruvate in gluconeogenesis?
Definition
Alanine and Lactate
Term
How is lactate generated to make pyruvate for Gluconeogenesis?
Definition
Lactate is a byproduct of anaerobic glycolysis
Term
How is alanine generated to make pyruvate for Gluconeogenesis?
Definition
Protein stores in the muscles are degraded via proteolysis to form free amino acids which are then converted to amino acids
Term
How is lactate converted to pyruvate?
Definition
Through LDH in the liver
Term
How is alanine converted to pyruvate in the liver?
Definition
Through the process of ureagenesis
Term
What are the by products Ureagenesis?
Definition
Pyruvate and Urea
Term
Where does the glycerol come from in gluconeogenesis?
Definition
The glycerol comes from the degradation of triglycerides in adipose tissues
Term
What is the process by which triglycerides are converted into fatty acids?
Definition
Lipolysis
Term
How are free fatty acids transported in the body?
Definition
Since the fatty acids are water insoluble they have to be transfered with albumin
Term
What is the process that degrades fatty acids into ATP?
Definition
Beta-Oxidation
Term
What are the products of fatty acids degraded in the liver?
Definition
ATP, CO2, and Ketone Bodies
Term
What is the process that creates Ketone Bodies from fatty acids?
Definition
Ketogenesis
Term
Where are ketone bodies degraded?
Definition
In muscle
Term
What is the process by which Ketone bodies are degraded?
Definition
Ketogenolysis
Term
In what tissues will beta oxidation occur?
Definition
Adipose Tissue, Liver, and Muscles. Any aerobic cells except the brain
Term
What are the products of Lipolysis?
Definition
Fatty acids and Glycerol
Term
What process phosphorylates Glycerol in the liver?
Definition
Glycerol Kinase
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