Term
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Definition
| immediately at the onset of brain injury |
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Term
| Brain necrosis occurs as cells... |
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Definition
| lose membrane integrity, rupture, release intracellular components into extracellular space |
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Term
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Definition
| Further neurologic damage subsequent to primary injury over days or weeks |
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Term
| What does necrosis follow? |
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Definition
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Term
| What does apoptosis follow? |
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Definition
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Term
| What ensues if ATP levels fall profoundly? |
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Definition
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Term
| What ensues if ATP level is partially maintained? |
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Definition
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Term
| Mild reductions in ATP is associated with what (relative to cell viability) |
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Definition
| reversible injury and cellular recovery |
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Term
| when does ischemia occur? |
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Definition
| when blood is below the level neeed to meet metabolic demands (of brain tissue) |
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Term
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Definition
| deficiency of oxygen at the cellular level as a result of decreadd blood flow or ddecreaded blood oxygenation. |
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Term
| What is different about brain tissue relative to other tissues in the body? |
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Definition
| It requires 15% of total cardiac output and 20% of body's oxygen consumption, while only constituting 2% of body weight, except in Rhonda b/c she's so damn smart |
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Term
| How long does it take to cause irreversible brain damage in humans due to loss of ATP? |
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Definition
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Term
| What can lead to a loss of neuronal integrity? |
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Definition
| Toxicity from H+ ions, due to a continuance of Glycolysis in an ischemic cell |
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Term
| How much of the ATP in a typical neuron is consumed by the Na/K pump? |
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Definition
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Term
| Contains calcium transporters that sequester calcium ions |
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Definition
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Term
| Why as ischemic cells prone to calcium overload? |
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Definition
| pumps that move calcium out othe cell ar energy dependent |
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Term
| Name an excitotoxin and two receptors linked to it. |
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Definition
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Term
| with concomitant ischemia, reuptake mechanisms fail to remove excess what from the synapse bc they are energy dependent processes |
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Definition
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Term
| secondary injury due to free radical accumulation and the influx of inflammatory cells after re-establishing blood flow |
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Definition
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