Herpes

Inhibit DNA Polymerase by thymidine kinase

-PO for Herps 1&2

-IV for Encephalitis

Inhibi M2-> block H+

-Infuenza A

Inhibit M2--> Block H+

Influenza A

Neuramidase Inhibitor

Flu A&B

Neuramidase Inhibitor

Influenza A&B

HIV

Fusion/Entry Inhibitor (Gp41 binding)

HIV1 only

HIV

Protease Inhibitor (new Virus won't mature)

HIV

Integrase Inhibitor- Blocks DNA strand Transfer

Reverse Transcriptase Inhibitor

(Non Nucleoside)

Reverse Transcriptase Inhibitor (HIV)

Nucleoside Mimicking

Anti-Fungal

Binds Ergosterol-->Pores in Membrane

Broadest Spectrum

Anti fungal

inhibit steroid biosynthesis-topical

interfere with p450

Anit-Fungal

Inhibit Ergosterol-BBB

Common systemic antifungal

Anti-Fungal

Inhibit DNA synthesis-antimetabolic

(synergistic with amphoteracin)

Anti Fungal

Inhibit Cell membrane synthesis (B(1-3) Glucan)

Anti-Fungal

Systemic Ringworm

Disrupt Mitotic Spindle

Anti Fungal

Ergosterol Binding--> Creates pores

Not absorbed, stays local!

Beta Lactam

+ and -

Betalactam

+,- for psudomonas and enterobacter

1st Generation

(+)

Surgery Prophylaxis

2nd Generation 

Better (-), Worse (+) than 1st

S. pneumonia, H flu, M catarallis

"Respiratory Cephalosporin"

3rd Generation

Strep pneumo, H flu, Neissieria

Crosses BBB

3rd Generation

Pseudomonas

(aztreonam cross reactivity)

Cefepime

4th Gen

Enterobacter and pseudomonas

BBB-Meningitis

Aztreonam

Beta Lactam

Aerobic (-) (narrow)

(ceftazidime cross reactivity)

Beta Lactam

Broad

Induces B lactamase

(synergistic with aminoglycosides)

Glycopeptide

Time Dependent

PO=Cdiff  IV=(+)

Hypersensitivy, Hypotension, Redman

Glycopeptide

Concentration Dependent

VRSA, GISA, VRE

1st Gen Macrolide

Broad

Induce Ribosome Methylation

Poor Bioavailability, binds CYP3A4

bacteriostatic

Clarithromycin

2nd Gen Macrolide

Better bioavailability than erythro

bacteriostatic

3rd Gen Macrolide

Evades Efflux Pumps and doesn't induce ribosome methyl

S pneumo, pyogenes

bacteriostatic

Broad

Competes and inhibits macrolides

bacteriocidal

lipophobic, requires transport, binds 30s

(-), (+) with synergistic beta lactams

oto and nephrotoxic

concentration dependent

Bacteriostatic

Binds 30s, prevents dna translocation

Inhibit bone growth, discolor teeth, superinfection

Bacteriocidal-conc dpnt

free radicals destroy dna

+ and -, giardia

acetylaldehyde hangovers

Levofloxacin

(fluoroquniolone)

Dna gyrase inhibitor

S pneumo

Cartilage damage <17 or pregnant

Bacteriostatic

Inhibit dna synth pathway

synergistic with trimethoprim

aseptic meningitis bad!

induce PABA

Synergistic with sulfas

skin and organ adverse rxn

Rifampin

Broad

RNA polymerase

inhibit contraceptive

Red discoloration

Mycobacteria Tuberculosis

Isoniazid

Inhibits mycolic acid cell wall

narrow

cannot use by itself d/t resistance