Term
|
Definition
Unionized in acid pH of stomach, but small surface area
Ionized in less acidic pH of small intestine, but larger surface area |
|
|
Term
|
Definition
| Does not reach CNS in sufficient concentration to be effective |
|
|
Term
|
Definition
| Lipid soluble, metabolism resistant |
|
|
Term
|
Definition
Methylated morphine → morphine
Methylation via CYP
Mild analgesic, opioid antitussive
Rapid conversion, some people lack enzyme (polymorphism) |
|
|
Term
|
Definition
Pathway of metabolism
Glucocordination, sulfonation, guthianone pathway. Toxicity upon saturation. |
|
|
Term
|
Definition
Inhibition of CYPs (3A4)
Enhances drug effect |
|
|
Term
| Cigarette smoking, charcoal broiling, barbiturates |
|
Definition
Increases drug metabolism
Decreased therapeutic response |
|
|
