Term
| Most variable stage of cell cycle |
|
Definition
|
|
Term
| Cell cycle stage most susceptible to radiation therapy |
|
Definition
|
|
Term
| Cell cycle stage where most growth factors act |
|
Definition
|
|
Term
| Addition co-factor that increases effectiveness of radiation therapy |
|
Definition
|
|
Term
| Approach to biopsy of suspected sarcoma of the extremity |
|
Definition
# if < 4 cm- excisional biopsy
# if > 4 cm- incisional through a longitudinal incision because longitudinal incision has less lymphatic disruption and it's EASIER TO EXCISE SCAR IF THE BX MARGIN IS POSITIVE |
|
|
Term
| Post-op tx of extremity sarcoma |
|
Definition
| RT if high grade, close margins or tumor > 5 cm |
|
|
Term
Li Faumeni syndrome
# mutation
# associated malignancies |
|
Definition
# p53 mutation
# breast, brain, sarcomas and leukemia |
|
|
Term
| Method of spread of sarcomas |
|
Definition
|
|
Term
|
Definition
| based on grade, not size or nodes |
|
|
Term
| Tumor marker for colon CA |
|
Definition
|
|
Term
| Tumor marker for liver CA |
|
Definition
|
|
Term
| Tumor marker for pancreatic CA |
|
Definition
|
|
Term
| Tumor marker for ovarian CA |
|
Definition
|
|
Term
| Tumor marker for testicular CA |
|
Definition
|
|
Term
| Tumor marker for choriocarcinoma CA |
|
Definition
|
|
Term
| Genes involved in the development of colon CA |
|
Definition
|
|
Term
| Genes involved in the development of breast CA |
|
Definition
p53
bcl-2
c-myc
c-myb
her 2/neu |
|
|
Term
| Genetics/mutations of medullary thyroid cancer |
|
Definition
| Ret proto-oncogene on chromosome 10 |
|
|
Term
| Management of pts with confirmed ret proto-oncogene |
|
Definition
| prophylactic thyroidectomy |
|
|
Term
| MC cause of CA-related death in women |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Cancers a/w c-myc proto-oncogene |
|
Definition
small cell lung CA
Neuroblastoma
Burkitt's lymphoma |
|
|
Term
| Function of sis proto-oncogene |
|
Definition
| platelet derive growth factor defect |
|
|
Term
| Function and importance of erb B proto-oncogene |
|
Definition
epidermal growth factor defect
A/w decreased survival in breast CA |
|
|
Term
| Function and importance of k ras proto-oncogene |
|
Definition
# encodes for GTP protein
# involved in 90% of pancreatic CA, 50% of colon CA, and some lung CA |
|
|
Term
| Chemotherapeutic agents a/w pulmonary fibrosis |
|
Definition
|
|
Term
| Chemotherapeutic agents a/w neurotoxicity |
|
Definition
| vincristine and cisplatin |
|
|
Term
| Function and use of Levamisole |
|
Definition
| immunostimulant; anti-helminthic agent |
|
|
