Term
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Definition
| Variation in the size of RBCS |
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Term
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Definition
| Variation in the shape of RBCs |
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Term
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Definition
| PArticles made up of various substances not normally found in a RBC. |
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Term
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Definition
| 6-8microns, round bioconcave, pink to reddish orange, normal central pallor 2-3um, No inclusions, 90% hemoglobin. |
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Term
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Definition
smaller than normal RBC <5microns.
Seen in: lead deficiency, thalassemia, lead poisoning, anemia of chronic disorders. |
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Term
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Definition
LArger than RBCs >8microns.
Seen in: Liver disease, hypothyroidism, megaloblastic anemia, chemotherapy, normal in newborns. |
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Term
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Definition
| pale cell with increased central pallor, result of decreaed Hgb and iron production. |
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Term
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Definition
| RBCs with a faint blue color (due to RNA) larger than normal RBCS are actually reticulocytes. |
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Term
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Definition
arranged in stacks like coins.
Causes: increased plasma protein, multiple myeloma, macroglobulinemia. |
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Term
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Definition
Clumping of cells
Causes: antigen/anitbody reaction, autoimmune hemolytic anemia. |
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Term
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Definition
Lacks the bi-concave shape, no central pallor, increased Hgb.
Hereidtary spherocytosis, hemolytic anemia, post transfusion. |
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Term
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Definition
oval or egg shaped, ovalocytes are more egg shaped, elliptocytes more pencil shaped.
Ovalocytes: Thalassemia, Megaloblastic Anemia.
Elliptocytes: Hereditary elliptocytosis, Iron deficiency anemia. |
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Term
| Echinocyte (crenated RBC or burr) |
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Definition
roudned spicules, hypertonic saline, generally technical error.
Hypernatremia |
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Term
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Definition
similar to echinocytes, irregulary spaced spicules, uneven projections, blunt.
Liver disease, alcoholism, post-splenectomy, Vitamin E defic. |
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Term
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Definition
fragmented cells, bizarre looking, alert immediate med. eval.
Disseminated Intravascular Coagulation, hemolytic anemia, artifical heart valves. |
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Term
| Drepanocyte (sickle cell) |
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Definition
Crescent shaped cells, resembles a sicle with two pointed ends, rigid and inflexible.
Sickle Cell anemia due to hemoglobin S |
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Term
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Definition
hypochromic target shaped cells, excess cell mebrane in relation to Hgb present, appear when Hgb is affected.
Hallmark cell of liver disease, Hgb C disease, post splenectomy. |
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Term
| Dacrocyte (tear drop cell) |
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Definition
pear or teardrop shaped, elongated tail at one end, seen when cells pass through the spleen.
Thalassemia, iron deficiency. |
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Term
| Keratocyte ( bit cell or helmet cell) |
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Definition
half moon shaped with two or more spicules, deformed but typically normal volume.
Glucose-6-phosphate dehydrogenase defic, pulmonary embolism, disseminated intravascular coagulation. |
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Term
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Definition
Have a central pallor that has more of a slit than a round shape, lack bioconcave shape.
Chronic liver disease, hereditary stomatocytosis, hereditary spherocytosis. |
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Term
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Definition
remnants of DNA, appear round, deep purple granules within the RBC, eccentrically located, RBC maturation is rushed.
One post splenectomy
multiple, megaloblastic anemia |
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Term
| Pappen-heimer bodies (siderotic granules) |
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Definition
small, beaded blue-purple granules of free iron, RBC periphery, distinuished using {Russian blue stain.
Hereditary Hemachromatosis, Iron loading anemias, Thalassemia, post splenectomy. |
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Term
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Definition
Dark blue granules (RNA) located throught cytoplasm dustlike or coarse appearance.
Lead poisoning or thalessemia. |
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Term
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Definition
Thin, twisted (figure 8), threadlike strands.
Very Rare, lead poisoning |
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Term
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Definition
aggregates of denatured precipitated Hgb, Crystol Violet stain or brilliant cresyl blue, taken out by spleen, leads to bite or helmet cells.
G6PD defic, Alpha Thalassemia |
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Term
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Definition
| Plasmodiu, species of the malarial disease, |
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