Term
| All TLRs signal thru MyD88 except? |
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Definition
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Term
| Give examples of PAMPs and DAMPs? |
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Definition
ssRNA(virus), dsRNA(virus), flagellum (bacteria), LPS(GNB), lipoteichoic acid (GPB)
HSPs and monosodium urate |
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Term
Which toll like receptors are intracellular and which are extracellular?
Which two toll like receptors form dimers with TLR 2? |
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Definition
TLR 3 (RNA), 7 (RNA), 8 (RNA), 9 (DNA)
TLR 1, 2 (lipopeptides, peptidoglycan), 4 (LPS), 5 (flaggelin), 6 (Lipopeptides)
TLR 1 and 6 |
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Term
| What are the four types of dendritic cells and what is the progenitor line? |
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Definition
Myeloid (myeloid)
Plasmacytoid (lymphoid)
Langerhan (myeloid)
Interstitial (myeloid) |
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Term
| Give examples of activating and inhibitory receptors of NK cells and their ligands. |
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Definition
DAP10-NKG2D binds MIC-A and MIC-B (activating)
DAP12-CD94 binds HLA-E (activating)
NKG2A-CD94 binds HLA-E (inhibitory) |
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Term
Name members of the pentraxin family of proteins.
Name three endogenous pyogens. |
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Definition
CRP, SAP (acute phase reactants)
PTX3 (protects against Aspergillus fumigatus)
TNF, IL-1, IL-6 |
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Term
| What fragments are generated with cleavage of IgG molecules by papain and pepsin? |
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Definition
Fab x 2 and Fc
F(ab')2 and peptide fragments |
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Term
| What is the most variable region of the Ig molecule? |
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Definition
| CDR3 in the hypervariable region |
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Term
| What two proteins regulate folding of an antibody ? |
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Definition
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Term
Name the portion of the antigen where the antibody binds.
What is the term for multiple determinants in an antigen?
What is the term for a large complex formation?
What is the results of somatic hypermutation in the variable region of antibody genes? |
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Definition
Determinant or epitope
Multivalency
Zone of equivalence
Affinity maturation |
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Term
| Name 3 selectins and their ligands? Name 4 integrins and their ligands? |
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Definition
P-selectin and E-selectin on endothelium bind to sialyl Lewis X on leukocyte
L-selectin on leukocyte binds to PNAd on lymph node
LFA-1 (CD11aCD18) binds to ICAM1
VLA-4 (CD49aCD29) binds to VCAM1 and NCAM
Mac-1 (CD11bCD18) binds to ICAM1
alpha4beta7 binds to MadCAM1 |
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Term
| Name a few common names for chemokines and receptors |
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Definition
| MIP-1alpha (CCL3), MIP-1beta (CCL4), RANTES (CCL5 -CCR1,3,5), eotaxin (CCL11 - CCR3), Tarc (CCL17 - CCR4), IL-8 (CXCL8 - CXCR1,2), fractalkine (CX3CL1) |
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Term
| What are the phenotype markers for helper T cells, cytotoxic T cells, regulatory T cells, gammadelta T cells, B cells, NK cells and NKT cells? |
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Definition
Helper - CD3, CD4
Cytotoxic - CD3, CD8
Regulatory - CD3, CD4, CD25
Gammadelta - CD3, CD4, CD8 variable
B - Fc receptors, class II MHC, CD19, CD21
NK - CD16
NKT - CD16, CD3 |
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Term
| What are the surface protein expression of naive T cell, activated T cell, memory T cell, naive B cell, activated B cell, and memory B cell? |
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Definition
Naive T cell - L-selectin(CD62L), IL-7R(CD127), CCR7, CD45RA
Activated T cell - IL-2R(CD25), CD44, CD45R0
Memory T cell - IL-7R(CD127), CD44, CD45R0
Naive B cell - CXCR5
Activated B cell - CD27
Memory B cell - CD27 |
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Term
| What is needed for differentiation to Th1, Th2, Th17 and Treg cells and what cytokines stimulate these processes? |
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Definition
Th1 - Tbet, STAT-4, stimulated by IL-12 and IFNgamma
Th2 - GATA3, STAT-6, stimulated by IL-4
Th17 - RORgammaT, STAT-3, stimulated by IL-6, IL-1 and TGFbeta
Treg - FoxP3 |
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Term
| What causes maturation of eosinophils and dendritic cells? |
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Definition
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Term
| What two cytokines downregulate inflammation and induce tolerance? |
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Definition
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Term
These TLR are associated with these diseases
HSV encephalitis
Aspergillosis
Adrenal insufficiency
Leprosy and TB |
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Definition
TLR 3,7,8,9
TLR 4
TLR 2,4
TLR 2 |
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Term
| What is expressed on monocytes and what causes migration to peripheral tissue? |
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Definition
CD14 (component of TLR4) and CD16
VLA-4/VCAM-1 |
|
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Term
What is expressed on macrophages?
What activates them?
What scytokines do they secrete? |
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Definition
CD14, CD11b/CD18 (Mac-1), CD36
IFNgamma, LPS
TNFalpha |
|
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Term
What activates Eosinophils?
What causes migration to tissue?
What can be used to protect the presence of these cells? |
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Definition
GM-CSF, IL-3 and IL-5
RANTES, eotaxin
MBP |
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Term
| What causes hypereosinophilia? |
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Definition
| GI, allergy, malignancy (hodgkins), skin (eczema, pemphigoid), arteritis (CVD), drug reaction, hematologist disease (hypereosinophilic syndrome, mastocytosis), lung disease (ABPA, loeffler's syndrome, eosinophilic pneumonia, churg-Strauss), parasites |
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Term
| What attracts neutrophils to tissues? |
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Definition
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Term
| What is the major high-affinity phagocyte receptor? |
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Definition
| FcgammaI (binds IgG1 and IgG3) |
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Term
Which receptor is involved in antibody-dependent cell-mediated cytotoxicity (ADCC)?
ADCC by eosinophils and high affinity receptor? |
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Definition
FcgammaIIIA (CD16) Receptor on NK cells
FcepsilonRI (killing helminithic parasites) |
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