Term
|
Definition
natural penicillin
IV form
Spectrum:
Good: treponema pallidum, most strep
Mod: strep pneumo, enterococci
Poor: everything else |
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Term
|
Definition
natural penicillin
oral form of pen G
Good: treponema pallidum, most strep
Mod: strep pneumo, enterococci
Poor: everything else |
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Term
|
Definition
antistaphylococcal PCNs
Spectrum:
Good: MSSA, strep
Poor: G- rodds, enterococci, anaerobes, MRSA |
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Term
|
Definition
antistaphylococcal PCNs
Spectrum:
Good: MSSA, strep
Poor: G- rodds, enterococci, anaerobes, MRSA |
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Term
|
Definition
antistaphylococcal PCNs
Spectrum:
Good: MSSA, strep
Poor: G- rodds, enterococci, anaerobes, MRSA |
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Term
|
Definition
antistaphylococcal PCNs
Spectrum:
Good: MSSA, strep
Poor: G- rodds, enterococci, anaerobes, MRSA |
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Term
|
Definition
antistaphylococcal PCNs
Spectrum:
Good: MSSA, strep
Poor: G- rodds, enterococci, anaerobes, MRSA |
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Term
|
Definition
AminoPCNs: improve G- coverage by being water soluble and passing through porin channels in cell wall
Good: strep, enterococci
Moderate: enteric G- rods, haemophilus
Poor: staph, anaerobes |
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Term
|
Definition
*DOC for susceptible enterococci
AminoPCNs: improve G- coverage by being water soluble and passing through porin channels in cell wall
Good: strep, enterococci
Moderate: enteric G- rods, haemophilus
Poor: staph, anaerobes |
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Term
|
Definition
*strongest/most frequently prescribed
antipseudomonal PCNs
Spectrum:
Good: pseudomonas aeruginosa, strep, enterococci
Moderate: enteric GNR, haemophilus
Poor: staph, anaerobes |
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Term
|
Definition
*not commonly used
antipseudomonal PCNs
Spectrum:
Good: pseudomonas aeruginosa, strep, enterococci
Moderate: enteric GNR, haemophilus
Poor: staph, anaerobes |
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Term
|
Definition
*oral, only good for UTIs
antipseudomonal PCNs
Spectrum:
Good: pseudomonas aeruginosa, strep, enterococci
Moderate: enteric GNR, haemophilus
Poor: staph, anaerobes |
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Term
|
Definition
antipseudomonal PCNs
Spectrum:
Good: pseudomonas aeruginosa, strep, enterococci
Moderate: enteric GNR, haemophilus
Poor: staph, anaerobes |
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Term
|
Definition
*good activity against acinetobacter baumanni
beta lactam/beta lactamase inhibitor combos
Spectrum:
Good: MSSA, strep, enterococci, anaerobes, enteric GNRs,
Moderate: GNR w advanced beta lactamases
Poor: MRSA, ESBL producing GNRs |
|
|
Term
|
Definition
*available orally
beta lactam/beta lactamase inhibitor combos
Spectrum:
Good: MSSA, strep, enterococci, anaerobes, enteric GNRs,
Moderate: GNR w advanced beta lactamases
Poor: MRSA, ESBL producing GNRs |
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Term
|
Definition
beta lactam/beta lactamase inhibitor combos
Spectrum:
Good: MSSA, strep, enterococci, anaerobes, enteric GNRs, pseudomonas aeruginosa
Moderate: GNR w advanced beta lactamases
Poor: MRSA, ESBL producing GNRs |
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Term
|
Definition
beta lactam/beta lactamase inhibitor combos
Spectrum:
Good: MSSA, strep, enterococci, anaerobes, enteric GNRs, pseudomonas aeruginosa
Moderate: GNR w advanced beta lactamases
Poor: MRSA, ESBL producing GNRs |
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Term
|
Definition
1st gen cephalorsporins
Spectrum:
Good: MSSA, strep
Mod: some GNR
Poor: enterocci, anaerobes, MRSA, pseudomonas |
|
|
Term
|
Definition
*available orally
1st gen cephalorsporins
Spectrum:
Good: MSSA, strep
Mod: some GNR
Poor: enterocci, anaerobes, MRSA, pseudomonas |
|
|
Term
|
Definition
*iv and oral
2nd gen cephalosporins
Spectrum:
Good: some GNR, Haemophilus, Neisseria
Mod: strep, staph
Poor: enterococci, MRSA, pseudomonas |
|
|
Term
|
Definition
*iv only. cephamycin = increased activity against GI anaerobes
2nd gen cephalosporins
Spectrum:
Good: some GNR, Haemophilus, Neisseria
Mod: strep, staph, anaerobes
Poor: enterococci, MRSA, pseudomonas |
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Term
|
Definition
*crosses BBB
3rd gen cephalosporin (cause C.diff)
Spectrum:
Good: strep, enteric GNR
Mod: MSSA
Poor: enterocci, pseudomonas, anaerobes, MRSA |
|
|
Term
|
Definition
*crosses BBB
3rd gen cephalosporin (cause C.diff)
Spectrum:
Good: strep, enteric GNR
Mod: MSSA
Poor: enterocci, pseudomonas, anaerobes, MRSA |
|
|
Term
|
Definition
*crosses BBB
3rd gen cephalosporin (cause C.diff)
Spectrum:
Good: strep, enteric GNR, pseudomonas
Poor: enterocci, pseudomonas, anaerobes, MRSA |
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|
Term
|
Definition
4th gen cephalosporin
Spectrum: MSSA, strep, pseudomonas, enteric GNRs
Mod: Acinetobacter
Poor: enterococci, anaerobes, MRSA |
|
|
Term
|
Definition
Carbapenem
Spectrum:
Good: MSSA, strep, anaerobes, enteric GNR, pseudomonas, acinetobacter, ESBL producing GNR
Mod: enterococci
Poor: MRSA, pen resistant strep |
|
|
Term
|
Definition
Carbapenem
Spectrum:
Good: MSSA, strep, anaerobes, enteric GNR, pseudomonas, acinetobacter, ESBL producing GNR
Mod: enterococci
Poor: MRSA, pen resistant strep |
|
|
Term
|
Definition
Carbapenem
Spectrum:
Good: MSSA, strep, anaerobes, enteric GNR, pseudomonas, acinetobacter, ESBL producing GNR
Mod: enterococci
Poor: MRSA, pen resistant strep |
|
|
Term
|
Definition
*less spectrum but once day so good for home infusion
Carbapenem
Spectrum:
Good: MSSA, strep, anaerobes, enteric GNR, ESBL producing GNR
Poor: MRSA, pen resistant strep |
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|
Term
|
Definition
*ceftazidime wo allergic cross-reactivity
monobactam
Good: pseudomonas, most GNR
Mod: Acinetobacter
Poor: G+, anaerobes |
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|
Term
|
Definition
glycopeptide
Good: MSSA, MRSA, strep, Cdiff
Mod: enterococci
Poor: anything G- |
|
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Term
|
Definition
FQ
Good: enteric GNR, H flu
Mod: pseduo, atypicals (myco, chlamydia, legionella) |
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|
Term
|
Definition
FQ
Good: enteric GNR, staph pneumo, atypicals, hflu,
Mod: pseudo, MSSA
Poor: anaerobes, enterocci |
|
|
Term
|
Definition
FQ
Good: enteric GNR, staph pneumo, atypicals, hflu,
Mod: MSSA, anaerobes
Poor: anaerobes, enterocci |
|
|
Term
|
Definition
FQ
Good: enteric GNR, staph pneumo, atypicals, hflu,
Mod: MSSA
Poor: anaerobes, enterocci |
|
|
Term
|
Definition
AMG
Good: gram negatives (ecoli, kleb, pseudo, acinetobacter)
Mod: in combo w beta lactam or glycopeptide- staph (w MRSA), viridans strep, enterococci
Poor: atypicals, anaerobes, G+ as mono |
|
|
Term
|
Definition
AMG
Good: gram negatives (ecoli, kleb, pseudo, acinetobacter)
Mod: in combo w beta lactam or glycopeptide- staph (w MRSA), viridans strep, enterococci
Poor: atypicals, anaerobes, G+ as mono |
|
|
Term
|
Definition
AMG
Good: gram negatives (ecoli, kleb, pseudo, acinetobacter)
Mod: in combo w beta lactam or glycopeptide- staph (w MRSA), viridans strep, enterococci
Poor: atypicals, anaerobes, G+ as mono |
|
|
Term
|
Definition
tetracycline
Good: atypicals, rickettsia, spirochetes (t. pallidum, b. burgdorferi, H. pylori)
Mod: staph w MRSA, s. pneumo, s. pyogenes
poor: most GNRs, anaerobes, enterococci |
|
|
Term
|
Definition
Glycylcyline
Good: atypicals, enterococci (including VRE), staph w MRSA, s. pneumo, s. pyogenes
Acceptable: most GN, anaerobes
Poor: pseudo, proteus, providencia, prevotella |
|
|
Term
|
Definition
tetracycline
Good: atypicals, rickettsia, spirochetes (t. pallidum, b. burgdorferi, H. pylori)
Mod: staph w MRSA, s. pneumo, s. pyogenes
poor: most GNRs, anaerobes, enterococci |
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|
Term
|
Definition
macrolide
Good: atypicals, hflu, moraxella, helicobater pylori, mycobacterium avium
Mod: s. pneumo, s. pyogenes
Poor: staph, enteric GNR, anaerobes, enterococci |
|
|
Term
|
Definition
macrolide
Good: atypicals, hflu, moraxella, helicobater pylori, mycobacterium avium
Mod: s. pneumo, s. pyogenes
Poor: staph, enteric GNR, anaerobes, enterococci |
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|
Term
|
Definition
*maoi
oxazolidinone
Good: MSSA, MRSA, strep, enterococci w vre, nocardia
mod: some atypicals
poor: all G-, anaerobes |
|
|
Term
|
Definition
*disulfuram rxn w alcohol
nitroimidazoles
good: G- and G+ anaerobes including bactericides, fusoact, clostridium, protozoa including trichomonas, entamoeba and giardia
mod: helicobacter pylori
poor: aerobic G-/G+, anaerobes of teh mouth |
|
|
Term
|
Definition
*only good for lower urinary tract infections
nitrofuran
Good: ecoli, staph sapro
mod: citrobacter, kleb, enterococci
Poor: pseudo, proteus, acinetobacter, serratia |
|
|
Term
|
Definition
*rhabdomyolysis
cyclic lipopeptide
Good: MSSA, MRSA, strep
Mod to good: enterococci including VRE
Poor: any G- |
|
|
Term
|
Definition
Good: staph aureus including some MRSA, hflu, stenotrophomonas, listeria, pneumocystis jirovecii
MOd: enteric GNR, s pneumo, salmonella, shigella, nocardia
poor: pseudo, anaerobes, enterococci, s progenies |
|
|
Term
|
Definition
*mix of vanc + metronidazole
Good: many G+ anaerobes
mod: staph aureus, strep pyogenes, g- anaerobes, chlamydia, p. jirovecii, actinomyces, toxoplasma
Poor: enterococci, cdiff, gram negative aerobes |
|
|
Term
|
Definition
polyene
Good: most species of candida/asergillus, crytococcus, dimorphic, many moulds
mod: zygomycetes
poor: candida lusitaniae |
|
|
Term
|
Definition
*monitorable levels. check peak 2 hours post dose
antimetabolite
good: in combo with ampho: cryptococcus, most species of candida
mod: mono: cryptococcus, most species of candida
poor: moulds, candida krusei |
|
|
Term
|
Definition
azole
Good: candida albicans, tropicalis, parapsilosis, lusitaniae, cryptococcus, coccidioides
mod: candida glabrata
poor: moulds, many dimorphic fungi, candida krusei |
|
|
Term
|
Definition
*capsules less BA than solution
broader spectrum azole
Good: candida albicans, tropicalis, parapsilosis, lusitaniae, cryptococcus, aspergillus, many dimorphic
poor: moulds, candida glabrata, zygomycetes, candida krusei |
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|
Term
|
Definition
*DOC for aspergillosis
Mould azole
Good: candida albicans, tropicalis, parapsilosis, lusitaniae, cryptococcus, aspergillus, many other moulds
Mod: C. glabrata, krusei, albicans that are flucon resistant, fusarium
poor: zygomycetes |
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|
Term
|
Definition
*analog of itra w more fungi activity. Mainly prophylaxis for high risk patients
Good: Good: candida albicans, tropicalis, parapsilosis, lusitaniae, krusei, aspergillus, many dimorphic, zygomycetes, moulds
Mod: fusarium, candida glabrata |
|
|
Term
|
Definition
*becoming DOC for invasive candidiasis
echinocandins
good: Good: candida albicans, glabrata, kruseitropicalis, lusitaniae, aspergillus,
mod: Candida parapsilosis, some dimorphic fungi
Poor: zygomycetes and most non-aspergillus moulds, cryptococcus neoformans |
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