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859-3 DUB
dysfunctional uterine bleeding
42
Health Care
Graduate
03/09/2012

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Term
what is an all-encompassing diagnosis referring to any uterine bleeding that is irregluar in amount, frequency, duration or timing?
Definition
AUB- abnormal uterine bleeding
Term
what is bleeding or spotting between normal menses, flow is usually light
Definition
intermenstrual bleeding
Term
what is excessive amount or prolonged duration of bleeding in excess of 80 ml at regular intervals?
Definition
menorrhagia
Term
what is heavy prolonged menstrual bleeding at irregular intervatls
Definition
menometrorrhagia
Term
what is uterine bleeding that is excessive in flow or duration or both at irregular intervals
Definition
metrorrhagia
Term
what is decreased scanty flow at intervals greater than 35 days?
Definition
oligomenorrhea
Term
what is regular, frequent menstruation at intervals less than 24 days
Definition
polymenorrhea
Term
What is a term typically used to escribe abnormal bleeding for which no pelvic pathology or underlying medical caus is found?
Definition
DUB- dysfunctional uterine bleeding
Term
What is a normal range of days for cycle interval
Definition
21-34
Term
what is a normal number of days for menstrual flow
Definition
3-8 days
Term
what is the most common cause of bleeding pattern that is suddenly different froma woman's established menstrual pattern
Definition
a complication of pregnancy (treatened or incomplete AB, ectopic, retained POC, molar preg) so always exclude this first
Term
what types of menses are associated with heavy, irregular bleeding
Definition
anovulatory cycles
Term
is ovulatory or anovulatory AUB more common?
Definition
anovulatory
Term
If a cycle is anovulatory, what phase of the menstrual cycle is the woman constantly in?
Definition
the proliferation phase
Term
What are endocrine causes of AUB
Definition
Thyroid disease, pituitary disease, PCOS, adrenal hyperplasia, cushings, diabetes
Term
What medications can cause AUB
Definition
amphetamines, anticoagulants, anyipsychotics, benzo's, corticosteroids, hormone therapy (tamoxifen), isoniazid, SSRI's
Term
Can herbs cause AUB?
Definition
yes, ginko, ginsing, soy and especially bromelain
Term
POF, PCOS, postmenarche, perimenopause, stress, eating disorders, severe dieting /weight loss, excessive exercise all cause problems with the_______ that can lead to AUB
Definition
hypothalamic-pituitary-ovarian axis
Term
What disorder do you want to look for in a woman >35 or obese women with DUB?
Definition
endometrial hyperplasia (from prolonged estrogen exposure)
Term
What infections may cause irregular spotting d/t irritation and inflamation of the tissues of the cervix or endometrium
Definition
gonorrhea, chlamydia, endometritis
Term
what benign gyn abnormalities may cause heavy or abnormal bleeding?
Definition
fibroids, adenomyosis, cervical polyps
Term
why would it be important to assess for violence in DUB?
Definition
trauma could cause lacerations/injuries
Term
If a woman taking OCP's for the first time presents with AUB, what should you assess?
Definition
that she is taking them correctly
Term
DUB diagnosis can be made based on menstrual history alone if no other risk factors are present and the patient has irregular, unpredictable bleeding in the absence of ____?
Definition
Molimina (PMS symptoms/ bloating fatigue constipation and mood changes) which are likely d/t higher levels of progesterone that does not occur in anovulatory cycles
Term
Is the passing of clots accompanied by heavy bleeding a reliable indicator for heavy bleeding?
Definition
Yes, counting pads or tampons has not been shown to be helpful
Term
Is it abnormal for a woman to report a change in the duration of flow from her normal?
Definition
yes
Term
A woman presents stating she is having regular cycles that have now become heavy and are acocompanied by the passage of clots and notices the sensation of pelvic fullness, what should you suspect as the cause
Definition
fibroids
Term
what symptoms could you ask about to reveal hormone disorders?
Definition
cold intolerance, fatigue, hyperactivity, weight loss or gain for thyroid
hair loss, changes in breast size, hirsuism, headache, breast discharge for hormone-secreting tumors
Term
easy bruising, petechiae, weight or appetite changes or changes in elimination patterns may be a sign of which of the following?
A. medication induced AUB
B. HPA axis disruption
C. systemic disease
Definition
Systemic disease (coagulation defects, von Willebrand, leukemia, ideiopathic thrombocytopenia, liver disease, renal disease)
Term
If a patient has pale skin, delayed capillary refill on exam and a history of heavy bleeding, what should you assess for?
Definition
anemia (CBC-Hg<10), serum iron/ferriten
Term
What cause of AUB may a breast exam help you rule out?
Definition
galactorrhea/pituitary tumor
Term
Can you defer a pelvic exam on an adolescent with AUB who is not sexually active?
Definition
Yes, as long as the patient only recently began menstruating and has a normal hematocrit
Term
Should you do a speculum exam and bimanual for women who are not adolescents?
Definition
Yes! look for infection, trauma, foreign objects w/ speculum, look for tumors, vervical polyps, ovarian cysts, uterine tenderness or enlargement, adenexal pain or masses with bimanual
Term
what lab test would help you to assess Von Willebrand disease if a patient has a hx of easy bruising or family hx of bleeding d/o (also assess for leukemia and prothrombin deficency)
Definition
PT/aPTT- bleeding time increased
Term
what hormone level would help you to assess for an anovulatory cycle
Definition
progesterone (less than 10ng/ml)between days 22 and 24, order if the menstrual hx does not indicate whether a woman is ovulating
Term
what lab test helps to r/o pituitary adenoma
Definition
prolactin (>100ng/ml) order if headaches, glactorrhea, peripheral vision changes
Term
what test would help test for clotting abnormalities
Definition
platelets less than 150,000
Term
What hormone level could help to show amenorrhea d/t menopause or POF
Definition
FSH (>30)
Term
What causes of AUB can TVS assess for?
Definition
polyps, submucosal fibroids, measure endometial thickness, evaluate for pregnancy complications, assess ovarian masses

good first line diagnostic tool
Term
What extra diagnostic test do you want tod o in a woman who has AUB and is perimenopausal, postmenopausal, adoselcents who are obeses and have long term (3+ years) of unexplained abnormal bleeding, or any women whose endometrium has been exposed to unopposed estrogen?
Definition
endometrial biopsy
Term
If the patient has heavy bleeding that is resulting in hemodynamic instability, what should you do?
Definition
send pt. to hospital
Term
For acute DUB that is not emergent, how should you treat?
Definition
any monophasic OCP q 12 H until bleeding stops (or 10 days)then continued with rest of package with one pill a day
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