Term
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Definition
Immunomodulator
2 Types: Alpha-2a (Roferon A) and alpha-2b (intron A)
Treat hairy cell leukemia and Kaposi's sarcoma and follicular lymphoma |
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Term
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Definition
| Immunomodulator used for Dukes' stage C colon cancer |
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Term
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Definition
Treats leprosy and multiple myeloma with Dexmethasone
Must be approved under STEPS (System for Thalidomide Education and Safety) |
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Term
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Definition
| Similar to Thalidomide for multiple myeloma |
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Term
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Definition
Immunomodulator used for metastatic renal-cell carcinoma
Also known as interleukin-2 |
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Term
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Definition
Immunomodulator- fusion protein composed of Diphtheria toxin fragments A and B and receptor binding portion interleukin-2
Treats Cutaneous T-cell lymphoma |
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Term
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Definition
Bacillus Calmette-Guerin
Treats in situ Urinary Bladder Carcinoma |
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Term
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Definition
| vaccine for treating androgen-indepdent prostate cancer |
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Term
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Definition
Target VEGF
Advanced colorectal cancer
HER2 breast cancer (FDA panel voted in July 2010 to rescind approval for this indication) |
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Term
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Definition
Target CD52
B-Cell chronic lymphocytic leukemia |
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Term
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Definition
| Target: EGFR HER1 (ErbB-1) |
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Term
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Definition
Target EGFR: HER2/neu (ErbB-2)
Treats Metastatic breast cancer and gastric cancer |
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Term
| ATRA (All-trans retinoic acid); tretinoin; Vesanoid |
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Definition
Retinoid
Mediated through retinoic acid receptors (RAR) and retinoid X receptors (RXR) |
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Term
| Acute promyelocytic leukemia (APL) |
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Definition
involves translocation of the retinoic acid receptor-alpha (RAR-alpha) from chromosome 15 to 17 -> abnormal fusion protein leads to loss of cell differentiation
Treat by Tretinoin (by reversing chromosomal translocation) |
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Term
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Definition
Bind to retinoid X receptor (RXR)
Bexarotene (Targretin) |
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Term
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Definition
| Rexinoid used to treat cutaneous T-cell lymphoma |
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