Term
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Definition
secrete mucins
- Makes a mucus layer to protect the epithelial cells from the gastric acid
- Epithelial cells secrete HCO3 that becomes trapped in mucus & makes mucus pH be 7 |
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Term
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Definition
secrete HCl
- Pumps H+ against the conc gradient with H+K+ ATPase enzyme on their membranes
o Each H+ into stomach is traded for a K+ into parietal cell
- Have receptors for histamine, gastrin, & acetylcholine |
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Term
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Definition
secrete pepsinogen
- Pepsinogen turns into pepsin in acidic environment (inactive at 4 pH)
- Pepsin cuts proteins/polypeptides |
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Term
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Definition
secrete 4 hormones:
- Histamine (activate parietal cells)
- Serotonin (stimulates stomach contraction & gut molitity)
- Gastrin (stimulate parietal cells to secrete HCl)
- Somatostatin (inhibits gastrin’s effects) |
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Term
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Definition
how the drug is designed and formulated to be a stable and safe medication
- Eg: Capsule, tablet, IV, cream, etc |
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Term
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Definition
rate & extent of drug absorption, distribution, & elimination from body
- Eg: insulin is rapidly absorbed |
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Term
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Definition
molecular interaction of drug with receptor
- Eg: binds to insulin receptors in myocytes |
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Term
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Definition
how the drug interacts with the body to produce biological/physiological effect
- Eg: assists muscle cells in glucose uptake from blood |
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Term
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Definition
| : ratio between min dose that is toxic for 50% people and min dose that is effective for 50% - higher the index, the safer the drug |
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Term
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Definition
2 different drugs with same effect combined will be the sum of the 2 apart
2 + 3 = 5 |
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Term
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Definition
2 different drugs with same effect combined will be HIGHER than sum of the 2 apart
2 x 3 = 6 |
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Term
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Definition
when an ineffective drug increased the effect of an effective drug
0 + 3 = 3 3 |
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