Term
|
Definition
| process by which one or more molecules of peg is chemically attached to a bio-molecule (usually protein) a peptide, or small molecule to improve PK and pd properties enabling them to attain better clinical potency |
|
|
Term
PEG is acidic/basic/neutral in water?
water sol or insol? |
|
Definition
|
|
Term
| what is the toxicity of peg? |
|
Definition
| is is non-toxic and few synthetic polymers approved for internal use by the FDA |
|
|
Term
how fast does peg move?
big or small volume? |
|
Definition
| moves rapidly, sweeps out a large volume (highly hydrated) |
|
|
Term
| What prevents PEG interavtions with proteins? |
|
Definition
| high hydration and rapid motion of PEG |
|
|
Term
| reasons to use PEG for drug delivery |
|
Definition
-enhanced drug solubility
increased drug stability (decreased protein aggregation_
-increased circulation time in blood, reduced proteolysis and reduced kidney clearance
-decreased immunogenicity
-targeting? |
|
|
